1-Hexanol, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Base Information

• Chemical Name: 1-Hexanol, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• CAS No.: 103202-59-1
• Molecular Formula: C12H28O2Si
• Molecular Weight: 232.439
• DSSTox Substance ID: DTXSID90458379
• Nikkaji Number: J1.257.065A
• Wikidata: Q82281621
• Mol file: 103202-59-1.mol

Synonyms:103202-59-1;1-Hexanol, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-;6-((tert-Butyldimethylsilyl)oxy)hexan-1-ol;6-[(dimethyl-(1,1-dimethylethyl)-silyl]-oxy]-hexanol;6-[[dimethyl-(1,1-dimethylethyl)-silyl]-oxy]-hexanol;6-(tert-butyldimethylsilyloxy)-1-hexanol;SCHEMBL1143253;DTXSID90458379;ROMDTZBCCCGPDR-UHFFFAOYSA-N;6-(tert-Butyldimethylsiloxy)-1-hexanol;6-(tert-butyldimethylsilyloxy)hexan-1-ol;6-{[tert.butyl(dimethyl)silyl]oxy}hexan-1-ol;F71782

Chemical Property of 1-Hexanol, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 8
• Exact Mass: 232.185856666
• Heavy Atom Count: 15
• Complexity: 162

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OCCCCCCO

Technology Process of 1-Hexanol, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

There total 5 articles about 1-Hexanol, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + C12H27BCl2O2Si → Trimethyl borate (121-43-7,63156-11-6) + 6-(tert-butyldimethylsilyl)oxyhexan-1-ol (103202-59-1)

Guidance literature:

DOI:10.1021/jo9913255

Reference yield: 95.0%

1-(tert-butyldimethylsilyloxy)-6-(triethylsilyloxy)-hexane (874796-87-9) → 1,6-hexanediol (629-11-8) + 6-(tert-butyldimethylsilyl)oxyhexan-1-ol (103202-59-1)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; In methanol; at 20 ℃; for 0.025h; Further Variations:; Reagents; Product distribution;

DOI:10.1016/j.tet.2005.10.043

Reference yield: 93.0%

tert-butyldimethyl{[6-({4-[(trimethylsilyl)methyl]benzyl}oxy)hexyl]oxy}silane (846539-31-9) → 6-(tert-butyldimethylsilyl)oxyhexan-1-ol (103202-59-1) + p-<(trimethylsilyl)methyl>benzaldehyde (109088-53-1)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 20 ℃;

DOI:10.1016/j.tet.2004.11.023

upstream raw materials:

methanol

tert-butyldimethyl{[6-({4-[(trimethylsilyl)methyl]benzyl}oxy)hexyl]oxy}silane

1-(tert-butyldimethylsilyloxy)-6-(triethylsilyloxy)-hexane

6-(tert-butyldimethylsilyloxy)hexyl acetate

Downstream raw materials:

Acetic acid (1R,2S,5R)-2-(1-{4-[6-(tert-butyl-dimethyl-silanyloxy)-hexyloxy]-phenyl}-1-methyl-ethyl)-5-methyl-cyclohexyl ester

tert-butyl-[6-(4-butyl-phenoxy)-hexyloxy]-dimethyl-silane

1-trityloxy-6-(tert-butyldimethylsilyloxy)hexane

C₁₈H₂₄O₃S₂