3-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-ol

Base Information

• Chemical Name: 3-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-ol
• CAS No.: 241491-18-9
• Molecular Formula: C₁₉H₃₁NO₂Si
• Molecular Weight: 333.546
• Mol file: 241491-18-9.mol

Synonyms:3-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-ol

Chemical Property of 3-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-ol

There total 1 articles about 3-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(allyl-benzyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester → 3-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-ol (241491-18-9)

Guidance literature:

With titanium(IV) isopropylate; isopropylmagnesium chloride; In diethyl ether;

DOI:10.1016/S0040-4039(99)00969-7

Reference yield:

3-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-ol (241491-18-9) → 1-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-chloro-piperidin-3-one

Guidance literature:

With iron(III) chloride; In diethyl ether;

DOI:10.1016/S0040-4039(99)00969-7

Reference yield:

3-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-ol (241491-18-9) → (2R,3R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-1,2,3,6-tetrahydro-pyridin-3-ol (241491-21-4)

Guidance literature:

Multi-step reaction with 3 steps

1: FeCl₃ / diethyl ether

2: NaOAc / methanol

3: 93 percent / NaBH₄; CeCl₃ / tetrahydrofuran; methanol

With sodium tetrahydroborate; cerium(III) chloride; sodium acetate; iron(III) chloride; In tetrahydrofuran; methanol; diethyl ether; 1: ring expansion / 2: Dehydrochlorination / 3: Reduction;

DOI:10.1016/S0040-4039(99)00969-7

Downstream raw materials:

(8S,8aR)-8-benzyloxy-1,5,8,8a-tetrahydrooxazolo[3,4-a]pyridin-3-one

Benzoic acid (8S,8aR)-3-oxo-1,5,8,8a-tetrahydro-oxazolo[3,4-a]pyridin-8-yl ester

1-benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-1,6-dihydro-2H-pyridin-3-one

(2R,3R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-1,2,3,6-tetrahydro-pyridin-3-ol