N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

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Chemical Name:N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide
CAS No.:1337930-68-3
Molecular Formula:C₃₃H₃₈N₆O₄
Molecular Weight:582.703
Hs Code.:

Synonyms:N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

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Chemical Property of N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

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Technology Process of N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

There total 6 articles about N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1229606-73-8
N-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxyacetamide

: 1337930-68-3
N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: With hydrogen; acetic acid; palladium 10% on activated carbon; In methanol; at 80 ℃; Thales H-cube;

Reference yield:

: 33631-05-9
2-amino-4-hydroxypyridine

: 1337930-68-3
N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C

1.2: 20 - 50 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / 0 - 20 °C

2.2: 0.25 h

3.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 48 h / Inert atmosphere

4.1: dichloromethane / 3 h / 20 °C

4.2: 18 h / 20 °C

5.1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 80 °C / Thales H-cube

With hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1229607-38-8
4-((4-nitronaphthalen-1-yl)oxy)pyridin-2-amine

: 1337930-68-3
N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / 0 - 20 °C

1.2: 0.25 h

2.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 48 h / Inert atmosphere

3.1: dichloromethane / 3 h / 20 °C

3.2: 18 h / 20 °C

4.1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 80 °C / Thales H-cube

With hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;