5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide

Base Information

Chemical Name:5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide
CAS No.:1186517-31-6
Molecular Formula:C₂₆H₂₅N₃O₂S
Molecular Weight:443.569
Hs Code.:

Synonyms:5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide

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Chemical Property of 5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide

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Technology Process of 5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide

There total 5 articles about 5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186519-22-1
5-(hydroxy(thiazol-2-yl)methyl)-4'-methylbiphenyl-3-carboxylic acid

: (R)-1-(6-methylpyridin-3-yl)ethanamine dihydrochloride

: 1186517-31-6
5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

Reference yield:

: 307353-32-8
3-bromo-5-hydroxymethylbenzoic acid methyl ester

: 1186517-31-6
5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 0 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / 95 °C / Inert atmosphere

4.1: water; lithium hydroxide / 1,4-dioxane / 4 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 25 °C

With manganese(IV) oxide; water; isopropylmagnesium chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1186519-21-0
methyl 3-bromo-5-(hydroxy(thiazol-2-yl)methyl)benzoate

: 1186517-31-6
5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / 95 °C / Inert atmosphere

2: water; lithium hydroxide / 1,4-dioxane / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 25 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;