307353-32-8

Usage

Uses

Used in Pharmaceutical Synthesis:
METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE is used as a building block for the production of various drugs and compounds. Its versatile chemical properties allow it to be incorporated into the synthesis of a wide range of pharmaceuticals, contributing to the development of new and improved medications.
Used in Agrochemical Synthesis:
In the agrochemical industry, METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE serves as an important intermediate in the synthesis of various agrochemicals. Its unique reactivity and chemical structure enable the creation of effective compounds for agricultural applications, such as pesticides and herbicides.
Used in Chemical Synthesis Research:
Due to its unique chemical properties and reactivity, METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE is an important target for further study and manipulation in the field of chemical synthesis. Researchers can explore its potential applications and develop new methods for its synthesis, leading to advancements in organic chemistry and the discovery of novel compounds.

Upstream product

• 220286-47-5 3-Amino-5-hydroxymethylbenzoic acid methyl ester 
• 51760-21-5 dimethyl 5-bromoisophthalate 
• 161796-10-7 3-bromo-5-(methoxycarbonyl)benzoic acid 

Downstream Products

• 877624-40-3 methyl 3-bromo-5-(bromomethyl)benzoate 
• 225657-76-1 3-(3-cyanophenyl)-5-(hydroxymethyl)benzoic acid methyl ester 
• 1334304-19-6 methyl 3-[(dimethylamino)methyl]-5-formylbenzoate 
• 1334304-20-9 methyl 3-(difluoromethyl)-5-[(dimethylamino)methyl]benzoate 
• 1334304-21-0 3-(difluoromethyl)-5-[(dimethylamino)methyI] benzoic acid 
• 1334304-18-5 methyl 3-[(dimethylamino)methyl]-5-(hydroxymethyl)benzoate 
• 1186517-97-4 3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide 
• 1186517-31-6 5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide 
• 1186520-10-4 3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid 
• 1186519-36-7 methyl 3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoate 
• 1186519-22-1 5-(hydroxy(thiazol-2-yl)methyl)-4'-methylbiphenyl-3-carboxylic acid 
• 1186519-92-5 methyl 5-(hydroxy(thiazol-2-yl)methyl)-4'-methylbiphenyl-3-carboxylate 
• 1186519-35-6 methyl 3-bromo-5-(1-(diethylamino)-2-hydroxyethyl)benzoate 

Relevant academic research and scientific papers

Synthesis and evaluation of tiaprofenic acid-derived UCHL5 deubiquitinase inhibitors

The ubiquitin–proteasome system (UPS) plays an important role in maintaining protein homeostasis by degrading intracellular proteins. In the proteasome, poly-ubiquitinated proteins are deubiquitinated by three deubiquitinases (DUBs) associated with 19S re

BENZOPYRAZOLE COMPOUND USED AS RHO KINASE INHIBITOR

The invention relates to a benzopyrazole compound used as RHO kinase inhibitor, a pharmaceutical composition and uses thereof for preparing an RHO kinase inhibiting drug, and more specifically to said compound of formula (I-1), a pharmaceutically acceptable salt and isomer thereof.

Discovery of a potent class of PI3Kα inhibitors with unique binding mode via encoded library technology (ELT4)

In the search of PI3K p110α wild type and H1047R mutant selective small molecule leads, an encoded library technology (ELT) campaign against the desired target proteins was performed which led to the discovery of a selective chemotype for PI3K isoforms from a three-cycle DNA encoded library. An X-ray crystal structure of a representative inhibitor from this chemotype demonstrated a unique binding mode in the p110α protein.

Broad substrate specificity of the amide synthase in S. hygroscopicus -new 20-membered macrolactones derived from geldanamycin

The amide synthase of the geldanamycin producer, Streptomyces hygroscopicus, shows a broader chemoselectivity than the corresponding amide synthase present in Actinosynnema pretiosum, the producer of the highly cytotoxic ansamycin antibiotics, the ansamit

AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF

Compounds are provided according to formula (1 ) : where A, B, W, X', L, R1, R3, R4b, and m' are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

NK-1 AND SEROTONIN TRANSPORTER INHIBITORS

The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.

QUINOXALINES AS B RAF INHIBITORS

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

PROCESS FOR PRODUCING 5-(3-CYANOPHENYL)-3-FORMYLBENZOIC ACID COMPOUND

A 5-(3-cyanophenyl)-3-formylbenzoic acid compound of the formula (IV) is prepared by reacting a 5-bromo-3-(hydroxymethyl)benzoic acid compound of the formula (I) with manganese dioxide to provide a 5-bromo-3-formylbenzoic acid compound of the formula (II)

Cyanobiphenyl derivatives

Intermediates represented by the following formula: (wherein R1is a hydrogen atom, an alkyl group, an aryl group, an aralkyl group or the like; X is a carboxyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, an aralkoxycarbonyl group,