AC-LEU-GLY-OH

Base Information

• Chemical Name: AC-LEU-GLY-OH
• CAS No.: 4033-42-5
• Molecular Formula: C₁₀H₁₈N₂O₄
• Molecular Weight: 230.264
• Mol file: 4033-42-5.mol

Synonyms:Glycine,N-(N-acetyl-L-leucyl)- (6CI,7CI,8CI); Acetylleucylglycine

Chemical Property of AC-LEU-GLY-OH

Chemical Property:

• PSA: 95.50000
• LogP: 0.51980
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

N-Acetyl-L-leucylglycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AC-LEU-GLY-OH

There total 4 articles about AC-LEU-GLY-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-acetyl-L-leucylglycine ethyl ester (909259-49-0) → N-acetyl-(S)-leucylglycine (90974-00-8,118142-32-8,4033-42-5)

Guidance literature:

N-acetyl-L-leucylglycine ethyl ester; With water; sodium hydroxide; In acetone; at 20 ℃; for 2h;

With hydrogenchloride; In water;

DOI:10.1016/j.tet.2010.06.075

Reference yield: 92.0%

Ac-Leu-Gly-OMe (17554-10-8) → N-acetyl-(S)-leucylglycine (90974-00-8,118142-32-8,4033-42-5)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jm300526r

Reference yield:

N-Ac-Leu (1188-21-2) → N-acetyl-(S)-leucylglycine (90974-00-8,118142-32-8,4033-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 0.17 h / 0 °C

1.2: 3.5 h

2.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

With water; benzotriazol-1-ol; lithium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm300526r

upstream raw materials:

N-acetyl-L-leucylglycine ethyl ester

Ac-Leu-Gly-OMe

N-Ac-Leu

Downstream raw materials:

Ac-Leu-Gly-Lys(Ac)-AMC

Ac-Leu-Gly-Lys(trifluroAc)-AMC

Refernces

• 1、 Seyedi, Seyed Mohammad,Sadeghian, Hamid,Jabbari, Atena,Assadi, Amir,Momeni, Hamideh. "Design and synthesis of a new series of amphiphilic peptide-β- cyclodextrins as phase transfer carriers for glucosamine". experimental part. p. 6754 - 6760. Retrieved 2010/10/01.