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N-Acetyl-L-leucine
Cas No: 1188-21-2
No Data 1 Gram 500 Kilogram/Month SICHUAN TONGSHENG AMINOACID CO.LTD Contact Supplier
99% up Ac-Leu-OH N-Acetyl-L-leucine 1188-21-2
Cas No: 1188-21-2
No Data 25 Kilogram 50 Metric Ton/Month Sinoway Industrial Co., Ltd. Contact Supplier
High quality N-Acetyl-L-Leucine supplier in China
Cas No: 1188-21-2
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
N-Acetyl-L-leucine
Cas No: 1188-21-2
USD $ 12.0-12.0 / Gram 100 Gram 200 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Manufacturer supply N-Acetyl-L-leucine CAS 1188-21-2 with best price
Cas No: 1188-21-2
USD $ 10.0-10.0 / Kilogram 1 Kilogram 30 Metric Ton/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
N-Acetyl-L-leucine
Cas No: 1188-21-2
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply N-Acetyl-L-Leucine
Cas No: 1188-21-2
No Data 1 1 Ality Chemical Corporation Contact Supplier
N-Acetyl-L-Leucine CAS#1188-21-2 AJI92
Cas No: 1188-21-2
No Data 25 Kilogram 30 Metric Ton/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
High Quality Food Grade N-Acetyl-L-Leucine 1188-21-2 HACCP Manufacturer
Cas No: 1188-21-2
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
N-Acetyl-L-leucine
Cas No: 1188-21-2
No Data 25 Kilogram 2000 Kilogram/Month Chengdu Baishixing Science and Technology Industry Co., Ltd. Contact Supplier

1188-21-2 Usage

Chemical Properties

White crystalline powder

Uses

N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

Definition

ChEBI: The N-acetyl derivative of L-leucine.
InChI:InChI=1/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/p-1/t7-/m0/s1

1188-21-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (A0098)  N-Acetyl-L-leucine  >99.0%(T) 1188-21-2 5g 220.00CNY Detail
TCI America (A0098)  N-Acetyl-L-leucine  >99.0%(T) 1188-21-2 25g 630.00CNY Detail
Alfa Aesar (L13926)  N-Acetyl-L-leucine, 99%    1188-21-2 5g 369.0CNY Detail
Alfa Aesar (L13926)  N-Acetyl-L-leucine, 99%    1188-21-2 25g 1366.0CNY Detail
Aldrich (441511)  N-Acetyl-L-leucine  ReagentPlus®, 99% 1188-21-2 441511-25G 1,267.11CNY Detail
Vetec (V900579)  N-Acetyl-L-leucine  Vetec reagent grade, 98% 1188-21-2 V900579-5G 272.61CNY Detail

1188-21-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N-acetyl-L-leucine

1.2 Other means of identification

Product number -
Other names (S)-2-Acetamido-4-methylpentanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1188-21-2 SDS

1188-21-2Synthetic route

(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid
64896-30-6

(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With hydrogen; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran at 20℃; under 750.075 Torr; for 24h;100%
With hydrogen; Rh(I)-(S)-chairphos In tetrahydrofuran Product distribution; Ambient temperature; other catalyst; other solvents; influence on products' optical yields;
With hydrogen; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine); [rhodium(I)(norborna-2,5-diene)2]SbF6 In dichloromethane at 20℃; under 1292.87 Torr; for 24h;
With chiral (1,1'-ferrocenediyl)bis(phospholo[3,4-d][1,3]dioxole); hydrogen; bis(1,5-cyclooctadiene)rhodium(I) hexafluorophosphate In tetrahydrofuran at 20℃; under 775.743 Torr; for 1h;
L-leucine
61-90-5

L-leucine

acetic anhydride
108-24-7

acetic anhydride

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
In water for 0.0666667h; Irradiation;98%
With sodium hydrogencarbonate In water at 0 - 20℃; for 5h;89%
With triethylamine In water at 20℃;35%
methyl N-acetyl-leucinate
57289-25-5

methyl N-acetyl-leucinate

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

methyl (R)-2-(N-acetylamino)-4-methylpentanoate
35799-87-2

methyl (R)-2-(N-acetylamino)-4-methylpentanoate

Conditions
ConditionsYield
With sodium hydroxide; phosphate buffer; pronase EC 3.4.24.4 In tetrahydrofuran Ambient temperature;A 79%
B 91%
L-Norvaline
6600-40-4

L-Norvaline

acetic anhydride
108-24-7

acetic anhydride

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
at 0 - 20℃;89%
(S)-benzyl 2-acetamido-4-methylpentanoate
244250-56-4

(S)-benzyl 2-acetamido-4-methylpentanoate

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h;81%
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h;81%
Ketene
463-51-4

Ketene

L-leucine
61-90-5

L-leucine

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With sodium hydroxide
N-acetylleucine
99-15-0

N-acetylleucine

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With (-)-α-fenchylamine
methyl N-acetyl-leucinate
57289-25-5

methyl N-acetyl-leucinate

N-Ac-Leu
1188-21-2

N-Ac-Leu

methyl N-acetyl-leucinate
57289-25-5

methyl N-acetyl-leucinate

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
for 118h; carbonate hydrolyase EC 4.2.2.1 (bovine carbonic anhydrase, BCA), pH 7.5; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
ethyl N-acetyl-leucinate
4071-36-7

ethyl N-acetyl-leucinate

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-O-ethyl-D-leucine
75552-78-2

N-acetyl-O-ethyl-D-leucine

Conditions
ConditionsYield
In ethanol; water at 35℃; for 48h; Yield given;
2-acetylamino-4-methyl-pent-2-enoic acid
915008-30-9

2-acetylamino-4-methyl-pent-2-enoic acid

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With hydrogen; <(2R,3R)-2,3-Bis(diphenylphosphino)butan>(ϖ-norbornadien)rhodium(I)-perchlorate In tetrahydrofuran under 3000.2 Torr; for 8h; Yield given;
2-acetylamino-4-methyl-pent-2-enoic acid
915008-30-9

2-acetylamino-4-methyl-pent-2-enoic acid

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With hydrogen; ClO4; (2R,3S)-1,2-bis(diphenylphosphino)-3-tBoc-aminobutane In ethanol for 22h; Ambient temperature; Yield given;
With ; hydrogen In ethanol at 20℃; under 760 Torr; Title compound not separated from byproducts;
(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid
64896-30-6

(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With <(1R;2R-MAC-PONP)Rh(COD)>(+)BF4(-); hydrogen In methanol at 30℃; under 750.06 Torr; Title compound not separated from byproducts;
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran under 760 Torr; for 24h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With hydrogen; triethylamine; ClO4; (2S,4S)-MOD-BPPM In ethanol at 50℃; under 15200 Torr; for 20h; Title compound not separated from byproducts;
(1'S,3S)-8-acetoxy-3-<1'-(acetylamino)-3'-methylbutyl>-3,4-dihydro-1-oxo-1H-2-benzopyran
85785-66-6

(1'S,3S)-8-acetoxy-3-<1'-(acetylamino)-3'-methylbutyl>-3,4-dihydro-1-oxo-1H-2-benzopyran

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With potassium permanganate; magnesium sulfate In water for 1.5h; Heating;
L-leucine
61-90-5

L-leucine

4-nitrophenol acetate
830-03-5

4-nitrophenol acetate

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
β‐cyclodextrin In water; dimethyl sulfoxide at 25℃; Rate constant; Mechanism; various conditions;
N-acetyl-DL-isoleucine butyl ester
2256-97-5

N-acetyl-DL-isoleucine butyl ester

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With rice bran lipase; sodium chloride at 30℃; pH=7.5; Title compound not separated from byproducts;
acetamide
60-35-5

acetamide

carbon monoxide
201230-82-2

carbon monoxide

isovaleraldehyde
590-86-3

isovaleraldehyde

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With sulfuric acid; lithium bromide; bis(triphenylphosphine)palladium dibromide In various solvent(s) at 120℃; under 45003.6 Torr; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
Ketene
463-51-4

Ketene

L-leucine
61-90-5

L-leucine

alkali

alkali

N-Ac-Leu
1188-21-2

N-Ac-Leu

DL-leucine methyl ester
18869-43-7

DL-leucine methyl ester

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaOCH3 / Brenner esterification
2: pyridine
3: H2O; ethanol / 48 h / 35 °C
View Scheme
DL-leucine ethyl ester
2899-43-6

DL-leucine ethyl ester

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: H2O; ethanol / 48 h / 35 °C
View Scheme
(3S)-3-<(1'S)-1'-amino-3'-methylbutyl>-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one
57765-73-8

(3S)-3-<(1'S)-1'-amino-3'-methylbutyl>-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / pyridine / 2 h / 50 °C
2: KMnO4, MgSO4 / H2O / 1.5 h / Heating
View Scheme
C8H13NO3
74839-85-3

C8H13NO3

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With {Rh[ZhangPhos](nbd)}BF4; hydrogen In methanol at 20℃; under 1034.32 Torr; for 12h; optical yield given as %ee; enantioselective reaction;
L-leucine
61-90-5

L-leucine

acetyl chloride
75-36-5

acetyl chloride

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane; water
L-leucine benzyl ester p-toluenesulfonate
1738-77-8

L-leucine benzyl ester p-toluenesulfonate

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 50 °C
View Scheme
(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

N-Ac-Leu
1188-21-2

N-Ac-Leu

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

Conditions
ConditionsYield
In methanol for 1h; Reflux;98.3%
In methanol at 65 - 70℃;
In methanol for 1h; Reflux;1670 g
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
253168-94-4

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

N-Ac-Leu
1188-21-2

N-Ac-Leu

1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-ethylamine N-acetyl-L-leucine salt

1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-ethylamine N-acetyl-L-leucine salt

Conditions
ConditionsYield
In methanol at 20℃; for 4h; Reflux;98%
N-Ac-Leu
1188-21-2

N-Ac-Leu

1,1,1,3',3',3'-hexafluoro-propanol
920-66-1

1,1,1,3',3',3'-hexafluoro-propanol

C11H15F6NO3

C11H15F6NO3

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 4.5h;98%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H19N

C12H19N

C20H32N2O2

C20H32N2O2

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 8h;96%
N-Ac-Leu
1188-21-2

N-Ac-Leu

chloroacetonitrile
107-14-2

chloroacetonitrile

C10H16N2O3

C10H16N2O3

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0 - 20℃; for 4.5h;96%
N-Ac-Leu
1188-21-2

N-Ac-Leu

(4R,5S)-1,5-Dimethyl-3-((2R,3S)-3-methyl-aziridine-2-carbonyl)-4-phenyl-imidazolidin-2-one
176791-95-0

(4R,5S)-1,5-Dimethyl-3-((2R,3S)-3-methyl-aziridine-2-carbonyl)-4-phenyl-imidazolidin-2-one

N-{(S)-1-[(2R,3S)-2-((4S,5R)-3,4-Dimethyl-2-oxo-5-phenyl-imidazolidine-1-carbonyl)-3-methyl-aziridine-1-carbonyl]-3-methyl-butyl}-acetamide
221374-48-7

N-{(S)-1-[(2R,3S)-2-((4S,5R)-3,4-Dimethyl-2-oxo-5-phenyl-imidazolidine-1-carbonyl)-3-methyl-aziridine-1-carbonyl]-3-methyl-butyl}-acetamide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane; acetonitrile for 12h; Ambient temperature;95%
N-Ac-Leu
1188-21-2

N-Ac-Leu

benzyl (R)-aziridine-2-carboxylate
86123-05-9

benzyl (R)-aziridine-2-carboxylate

benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate
260784-04-1

benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 6h; Acylation;95%
N-Ac-Leu
1188-21-2

N-Ac-Leu

(4R,5S,2'R)-1,5-dimethyl-3-[(2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one
199122-48-0

(4R,5S,2'R)-1,5-dimethyl-3-[(2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one

(4R,5S,2'R,2''S)-1,5-dimethyl-3-{[1'-(2''-acetamido-4''-methylpentanoyl)-2'-aziridinyl]carbonyl}-4-phenylimidazolidin-2-one
260783-98-0

(4R,5S,2'R,2''S)-1,5-dimethyl-3-{[1'-(2''-acetamido-4''-methylpentanoyl)-2'-aziridinyl]carbonyl}-4-phenylimidazolidin-2-one

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 6h; Acylation;95%
N-Ac-Leu
1188-21-2

N-Ac-Leu

2,2,2-trifluoroethyl trifluoromethanesulphonate
6226-25-1

2,2,2-trifluoroethyl trifluoromethanesulphonate

C10H16F3NO3

C10H16F3NO3

Conditions
ConditionsYield
Stage #1: N-Ac-Leu With caesium carbonate In acetonitrile at 20℃; for 0.333333h;
Stage #2: 2,2,2-trifluoroethyl trifluoromethanesulphonate In acetonitrile at 20℃; for 3h;
94%
formaldehyd
50-00-0

formaldehyd

N-Ac-Leu
1188-21-2

N-Ac-Leu

4-(S)-3-acetyl-4-isobutyl-5-oxazolidinone
125679-72-3

4-(S)-3-acetyl-4-isobutyl-5-oxazolidinone

Conditions
ConditionsYield
With K10 clay for 0.0333333h; Cyclization; microwave irradiation;93%
With diethyldichlorosilane Heating;60%
With toluene-4-sulfonic acid In benzene Heating;
With toluene-4-sulfonic acid In toluene
[(S)-1-((S)-1-{(S)-[(2R,3S)-2-((S)-1-Butylcarbamoyl-2-methyl-propylcarbamoyl)-tetrahydro-furan-3-yl]-hydroxy-methyl}-3-methyl-butylcarbamoyl)-3-methylsulfanyl-propyl]-carbamic acid tert-butyl ester
864366-92-7

[(S)-1-((S)-1-{(S)-[(2R,3S)-2-((S)-1-Butylcarbamoyl-2-methyl-propylcarbamoyl)-tetrahydro-furan-3-yl]-hydroxy-methyl}-3-methyl-butylcarbamoyl)-3-methylsulfanyl-propyl]-carbamic acid tert-butyl ester

N-Ac-Leu
1188-21-2

N-Ac-Leu

(2R,3S)-3-{(1S,2S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-4-methylsulfanyl-butyrylamino]-1-hydroxy-4-methyl-pentyl}-tetrahydro-furan-2-carboxylic acid ((S)-1-butylcarbamoyl-2-methyl-propyl)-amide

(2R,3S)-3-{(1S,2S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-4-methylsulfanyl-butyrylamino]-1-hydroxy-4-methyl-pentyl}-tetrahydro-furan-2-carboxylic acid ((S)-1-butylcarbamoyl-2-methyl-propyl)-amide

Conditions
ConditionsYield
With hydrogenchloride In various solvents at 0 - 5℃;92%
BOC-glycine
4530-20-5

BOC-glycine

N-Ac-Leu
1188-21-2

N-Ac-Leu

L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

N-(tert-butoxycarbonyl)-5-(N,O-dimethyl-hydroxamide)-glutamine

N-(tert-butoxycarbonyl)-5-(N,O-dimethyl-hydroxamide)-glutamine

Ph3P=CH-COOEt

Ph3P=CH-COOEt

(Z)-(S)-6-((S)-2-Acetylamino-4-methyl-pentanoylamino)-6-{(S)-1-[(S)-1-(carboxymethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-hex-2-enoic acid ethyl ester

(Z)-(S)-6-((S)-2-Acetylamino-4-methyl-pentanoylamino)-6-{(S)-1-[(S)-1-(carboxymethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-hex-2-enoic acid ethyl ester

Conditions
ConditionsYield
Solid phase reaction;90%
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
253168-94-4

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

N-Ac-Leu
1188-21-2

N-Ac-Leu

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

Conditions
ConditionsYield
In methanol at 20℃; for 8h; Reflux; Resolution of racemate;90%
Stage #1: 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine; N-Ac-Leu In methanol for 1h; Reflux;
Stage #2: In methanol at 20℃; for 4h; Reflux;
90%
In methanol at 20℃; for 4h; Reflux;90%
N-Ac-Leu
1188-21-2

N-Ac-Leu

diethyltin(IV) oxide
3682-12-0

diethyltin(IV) oxide

(C8H14NO3Sn(C2H5)2)2O

(C8H14NO3Sn(C2H5)2)2O

Conditions
ConditionsYield
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.;90%
N-Ac-Leu
1188-21-2

N-Ac-Leu

dimethyltin oxide
2273-45-2

dimethyltin oxide

(C8H14NO3Sn(CH3)2)2O

(C8H14NO3Sn(CH3)2)2O

Conditions
ConditionsYield
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.;90%
N-Ac-Leu
1188-21-2

N-Ac-Leu

methyl iodide
74-88-4

methyl iodide

N-acetyl-L-leucine methyl ester
1492-11-1

N-acetyl-L-leucine methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide89%
Stage #1: N-Ac-Leu With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 24h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 25℃; for 24h;
N-Ac-Leu
1188-21-2

N-Ac-Leu

N-methylglycine methyl ester hydrochloride
13515-93-0

N-methylglycine methyl ester hydrochloride

N-acetyl-L-leucyl-N-methylglycine methyl ester

N-acetyl-L-leucyl-N-methylglycine methyl ester

Conditions
ConditionsYield
Stage #1: N-Ac-Leu With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h;
Stage #2: N-methylglycine methyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;
89%
methanol
67-56-1

methanol

N-Ac-Leu
1188-21-2

N-Ac-Leu

N-acetyl-L-leucine methyl ester
1492-11-1

N-acetyl-L-leucine methyl ester

Conditions
ConditionsYield
With thionyl chloride at 0℃; for 4h;88%
N-Ac-Leu
1188-21-2

N-Ac-Leu

di(n-butyl)tin oxide
818-08-6

di(n-butyl)tin oxide

(C8H14NO3Sn(C4H9)2)2O

(C8H14NO3Sn(C4H9)2)2O

Conditions
ConditionsYield
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.;87%
N-Ac-Leu
1188-21-2

N-Ac-Leu

(S)-(9H-fluoren-9-yl)methyl (4,5-diamino-5-oxopentyl)carbamate

(S)-(9H-fluoren-9-yl)methyl (4,5-diamino-5-oxopentyl)carbamate

(9H-fluoren-9-yl)methyl ((S)-4-((S)-2-acetamido-4-methylpentanamido)-5-amino-5-oxopentyl)carbamate

(9H-fluoren-9-yl)methyl ((S)-4-((S)-2-acetamido-4-methylpentanamido)-5-amino-5-oxopentyl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In acetonitrile at 20℃; for 2h; Inert atmosphere;87%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H14(2)H3NO4S

C12H14(2)H3NO4S

C12H15(2)H4NO4S*C8H15NO3

C12H15(2)H4NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H14(2)H3NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 20 - 55℃;
86%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C15H17Cl2NO3

C15H17Cl2NO3

((S)-2-acetamido-4-methylpentanoyloxy)methyl (S)-1-(2-chlorophenyl)-2-oxocyclohexyl(methyl)carbamate

((S)-2-acetamido-4-methylpentanoyloxy)methyl (S)-1-(2-chlorophenyl)-2-oxocyclohexyl(methyl)carbamate

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In acetone at 70℃; for 1h;86%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-Ac-Leu
1188-21-2

N-Ac-Leu

N-acetyl-L-leucine N-hydroxysuccinimide ester
39740-61-9

N-acetyl-L-leucine N-hydroxysuccinimide ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃;85%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H14(2)H3NO4S

C12H14(2)H3NO4S

C12H13(2)H6NO4S*C8H15NO3

C12H13(2)H6NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H14(2)H3NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In methanol; 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 20 - 55℃;
85%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H10(2)H7NO4S

C12H10(2)H7NO4S

C12H11(2)H8NO4S*C8H15NO3

C12H11(2)H8NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H10(2)H7NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 20 - 55℃; for 1h;
85%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H5(2)H12NO4S

C12H5(2)H12NO4S

C12H5(2)H14NO4S*C8H15NO3

C12H5(2)H14NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H5(2)H12NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 55℃; for 1h;
85%
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