Cyclohexanecarboxaldehyde, 3,5-dimethyl-, (3R,5S)-rel- (9CI)

Base Information

• Chemical Name: Cyclohexanecarboxaldehyde, 3,5-dimethyl-, (3R,5S)-rel- (9CI)
• CAS No.: 328899-61-2
• Molecular Formula: C9H16 O
• Molecular Weight: 140.22274
• Mol file: 328899-61-2.mol

Synonyms:Cyclohexanecarboxaldehyde, 3,5-dimethyl-, (3R,5S)-rel- (9CI)

Chemical Property of Cyclohexanecarboxaldehyde, 3,5-dimethyl-, (3R,5S)-rel- (9CI)

Chemical Property:

• Boiling Point: 69 - 71 °C (14 mmHg)
• PSA: 17.07000
• LogP: 2.25760

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxaldehyde, 3,5-dimethyl-, (3R,5S)-rel- (9CI)

There total 1 articles about Cyclohexanecarboxaldehyde, 3,5-dimethyl-, (3R,5S)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3r.5c-dimethyl-cyclohexane-carbaldehyde-(1ξ) (328899-61-2)

Guidance literature:

With copper; at 170 - 180 ℃; under 150 Torr;

DOI:10.1021/ja01173a068

Reference yield:

3r.5c-dimethyl-cyclohexane-carbaldehyde-(1ξ) (328899-61-2) + acetone (67-64-1) → (+/-)-1-hydroxy-1-(3r.5c-dimethyl-cyclohexyl-(ξ))-butanone-(3)

Guidance literature:

With ethanol; sodium ethanolate; at -5 ℃;

DOI:10.1021/ja01173a068

Reference yield:

3r.5c-dimethyl-cyclohexane-carbaldehyde-(1ξ) (328899-61-2) → 6-Amino-4-((3S,5R)-3,5-dimethyl-cyclohexyl)-6'-morpholin-4-yl-[2,3']bipyridinyl-5-carbonitrile (328899-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: MgO / 1,2-dichloro-ethane

2: CH₂(CN)2; NH₄OAc / 1,2-dichloro-ethane / 80 °C

With ammonium acetate; magnesium oxide; malononitrile; In 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(00)00602-8

Downstream raw materials:

6-Amino-4-((3S,5R)-3,5-dimethyl-cyclohexyl)-6'-morpholin-4-yl-[2,3']bipyridinyl-5-carbonitrile