N-(6-benzoyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

Base Information

• Chemical Name: N-(6-benzoyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide
• CAS No.: 1449429-02-0
• Molecular Formula: C₂₆H₂₂Cl₂N₄O₅S₂
• Molecular Weight: 605.522
• Mol file: 1449429-02-0.mol

Synonyms:N-(6-benzoyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

Chemical Property of N-(6-benzoyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(6-benzoyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

There total 9 articles about N-(6-benzoyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ClH*C19H18Cl2N4O4S2 (1449428-77-6) + benzoyl chloride (98-88-4) → N-(6-benzoyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide (1449429-02-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride → N-(6-benzoyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide (1449429-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 20 °C

2: dichloromethane / 2 h / 20 °C / Acidic conditions

3: triethylamine / dichloromethane / 16 h / 20 °C

With pyridine; triethylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

2-amino-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid tert-butyl ester (150986-83-7) → N-(6-benzoyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide (1449429-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 20 °C

2: dichloromethane / 2 h / 20 °C / Acidic conditions

3: triethylamine / dichloromethane / 16 h / 20 °C

With pyridine; triethylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2013.05.013

upstream raw materials:

2-amino-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid tert-butyl ester

ClH*C₁₉H₁₈Cl₂N₄O₄S₂

benzoyl chloride

4-piperidone hydrochloride