Technology Process of (S,E)-1-((4-cyclohexylbut-3-en-2-yl)sulfonyl)-4-methylbenzene
There total 6 articles about (S,E)-1-((4-cyclohexylbut-3-en-2-yl)sulfonyl)-4-methylbenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
sodium 4-methylbenzenesulfinate;
With
bis(η3-allyl-μ-chloropalladium(II)); 1,1'-bisnaphthalene; boric acid;
In
1,4-dioxane;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
C10H19N;
In
1,4-dioxane;
at 20 - 100 ℃;
for 4.5h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/ja306407x
- Guidance literature:
-
With
palladium diacetate; (R)-9-(4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-yl)-9H-carbazole; toluene-4-sulfonic acid;
In
diethylene glycol dimethyl ether;
at 60 ℃;
for 24h;
Overall yield = 47 percent; enantioselective reaction;
Inert atmosphere;
Sealed tube;
DOI:10.1002/anie.202012485
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: L-Tartaric acid / ethanol / 24 h / 20 °C / Resolution of racemate
1.2: Resolution of racemate
2.1: bis(η3-allyl-μ-chloropalladium(II)); boric acid; 1,1'-bisnaphthalene / 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere
2.2: 4.5 h / 20 - 100 °C / Inert atmosphere
With
bis(η3-allyl-μ-chloropalladium(II)); L-Tartaric acid; 1,1'-bisnaphthalene; boric acid;
In
1,4-dioxane; ethanol;
DOI:10.1021/ja306407x
