4-chloro-5-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)phthalonitrile

Base Information

• Chemical Name: 4-chloro-5-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)phthalonitrile
• CAS No.: 1609258-82-3
• Molecular Formula: C₂₂H₁₅ClN₂O₂
• Molecular Weight: 374.826
• Mol file: 1609258-82-3.mol

Synonyms:4-chloro-5-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)phthalonitrile

Chemical Property of 4-chloro-5-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)phthalonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-5-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)phthalonitrile

There total 1 articles about 4-chloro-5-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)phthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.7%

(R,R)-hydroxybenzoin (52340-78-0) + 4,5-dichlorophthalonitrile (139152-08-2) → 4-chloro-5-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)phthalonitrile (1609258-82-3) + 5,5'-((1R,2R)-1,2-diphenylethane-1,2-diyl)bis(oxy)bis(4-chlorophthalonitrile) (1609258-83-4)

Guidance literature:

(R,R)-hydroxybenzoin; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 1h; Inert atmosphere;

4,5-dichlorophthalonitrile; In N,N-dimethyl-formamide; at 50 - 80 ℃; for 23.5h; Inert atmosphere;

DOI:10.1016/j.molstruc.2014.03.037

Reference yield: 22.0%

4-chloro-5-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)phthalonitrile (1609258-82-3) + zinc diacetate (557-34-6) → C88H60Cl4N8O8Zn

Guidance literature:

With quinoline; at 190 ℃; for 7h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.molstruc.2014.03.037

upstream raw materials:

(R,R)-hydroxybenzoin

4,5-dichlorophthalonitrile