Refernces
10.1016/S0040-4020(01)87794-2
The research explores the role of X=Y-ZH systems as potential 1,3-dipoles, focusing on the cycloadditions of arylidene imines of α-amino acid esters with a range of dipolarophiles. The study investigates the substantial rate enhancements observed in the presence of both Bronsted and Lewis acids. The purpose of the research is to understand the catalytic effects of these acids on the cycloaddition reactions and to determine the relationship between the rate of reaction and the pKa of the acid for Bronsted acids, as well as the order of rate acceleration for Lewis acids. The conclusions drawn from the research indicate that these reactions are regio- and stereo-specific, and the rate acceleration for Lewis acids follows the order Zn(OAc)2 > AgOAc > LiOAc > MgOAc, with anion dependence also playing a role. The chemicals used in the process include arylidene imines of α-amino acid esters, various dipolarophiles, Bronsted acids (such as 2,4-dinitrophenol, acetic acid, and others), and Lewis acids (such as Zn(OAc)2, AgOAc, LiOAc, and MgOAc). The study provides insights into the formation of metallo-1,3-dipoles and their role in cycloaddition reactions, contributing to the understanding of catalytic processes in organic chemistry.
10.1016/j.ica.2009.07.008
The research investigates the interaction of a novel hesperetin Schiff base ligand (H4L) and its copper(II) and zinc(II) complexes with DNA, as well as their antioxidative properties. The study aims to explore the binding mechanisms of these compounds to DNA and their potential as antitumor drugs and antioxidants. Key chemicals used include hesperetin, benzoyl hydrazine, copper(II) acetate, zinc(II) acetate, and calf thymus DNA. The researchers synthesized the ligand and its complexes and characterized them using various spectroscopic techniques. They found that all compounds bind to DNA through an intercalative mode, with the metal complexes showing stronger binding affinity than the free ligand. Additionally, the complexes exhibited higher antioxidative activity in scavenging superoxide radicals and hydroxyl radicals compared to the ligand. The findings suggest that these metal complexes could be valuable candidates for developing new antitumor drugs and antioxidants.
10.1002/(SICI)1099-0690(199912)1999:12<3441::AID-EJOC3441>3.0.CO;2-Y
The research focuses on the synthesis of novel functionalized zinc phthalocyanines, which are compounds with potential applications in photodynamic therapy (PDT) for cancer treatment. The purpose of the study is to develop water-soluble zinc phthalocyanines that can selectively bind to tumor-selective antibodies, thereby increasing the selectivity of PDT. The researchers successfully synthesized several new phthalonitriles and phthalocyaninatozinc compounds, including those with carboxyl groups and amino acid derivatives, which were found to be sufficiently soluble in water and exhibited weak tendencies to form stacked aggregates. In vitro experiments demonstrated that some of the new compounds, such as compound 27, showed good phototoxicity towards cancer cells, while others exhibited acute toxicity. The chemicals used in the synthesis process include 4,5-dibromocatechol, phthalonitriles, zinc(II) acetate, DBU, and various amino acid derivatives, among others. The conclusions drawn from the research suggest that these newly synthesized zinc phthalocyanines could be excellent sensitizers for singlet oxygen generation in PDT, and further investigations involving tumor-selective antibodies are ongoing.