8-Benzyloxyguanosine

Base Information

• Chemical Name: 8-Benzyloxyguanosine
• CAS No.: 3868-36-8
• Molecular Formula: C17H19 N5 O6
• Molecular Weight: 389.368
• Mol file: 3868-36-8.mol

Synonyms:Guanosine,8-(benzyloxy)- (7CI,8CI); 8-(Benzyloxy)guanosine; NSC 90391

Chemical Property of 8-Benzyloxyguanosine

Chemical Property:

• Boiling Point: 772°Cat760mmHg
• Flash Point: 420.7°C
• PSA: 168.74000
• Density: 1.8g/cm³
• LogP: -0.52650
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

8-(Benzyloxy)guanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Guanosine (G) derivative.

Technology Process of 8-Benzyloxyguanosine

There total 3 articles about 8-Benzyloxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

8-bromoguanosine (4016-63-1) + benzyl alcohol (100-51-6,185532-71-2) → 8-(benzyloxy)guanosine (3868-36-8)

Guidance literature:

benzyl alcohol; With sodium; at 65 ℃; for 2h;

8-bromoguanosine; In dimethyl sulfoxide; at 65 ℃; for 16h;

DOI:10.1016/j.bmcl.2019.126818

Reference yield:

8-bromoguanosine (4016-63-1) + sodium phenyl-methanolate (20194-18-7) → 8-(benzyloxy)guanosine (3868-36-8)

Guidance literature:

In dimethyl sulfoxide; at 65 - 70 ℃; for 42h;

DOI:10.1021/ja00129a004

Reference yield:

G (118-00-3) → 8-(benzyloxy)guanosine (3868-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / aq. Br₂

2: dimethylsulfoxide / 42 h / 65 - 70 °C

With bromine; In dimethyl sulfoxide;

DOI:10.1021/ja00129a004

upstream raw materials:

8-bromoguanosine

benzyl alcohol

sodium phenyl-methanolate

G

Downstream raw materials:

2',3',5'-tris((tert-butyldimethylsilyl)oxy)-8-benzyloxyguanosine

9-β-(D-ribofuranosyl)-1H-purine-2,6,8(3H,7H,9H)-trione

8-benzyloxy-xanthosine