N₂,N₆-bis[(benzyloxy)carbonyl]-D-lysyl-N₆-[(benzyloxy)carbonyl]-N-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-lysinamide

Base Information

• Chemical Name: N₂,N₆-bis[(benzyloxy)carbonyl]-D-lysyl-N₆-[(benzyloxy)carbonyl]-N-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-lysinamide
• CAS No.: 1375013-89-0
• Molecular Formula: C₅₅H₇₁N₇O₉
• Molecular Weight: 974.21

Synonyms:N₂,N₆-bis[(benzyloxy)carbonyl]-D-lysyl-N₆-[(benzyloxy)carbonyl]-N-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-lysinamide

Chemical Property of N₂,N₆-bis[(benzyloxy)carbonyl]-D-lysyl-N₆-[(benzyloxy)carbonyl]-N-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-lysinamide

Chemical Property:

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Technology Process of N₂,N₆-bis[(benzyloxy)carbonyl]-D-lysyl-N₆-[(benzyloxy)carbonyl]-N-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-lysinamide

There total 4 articles about N₂,N₆-bis[(benzyloxy)carbonyl]-D-lysyl-N₆-[(benzyloxy)carbonyl]-N-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-lysinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzyl ((5R)-5-amino-6-[(4-((2-tert-butyl-6-methoxyquinolin-8-yl)amino)pentyl)amino]-6-oxohexyl)carbamate (1267638-46-9) + Nα,Nε-Bis(benzyloxycarbonyl)-D-lysine (405-39-0,55592-85-3,69677-02-7) → N2,N6-bis[(benzyloxy)carbonyl]-D-lysyl-N6-[(benzyloxy)carbonyl]-N-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-lysinamide (1375013-89-0)

Guidance literature:

With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; Cooling with ice;

DOI:10.1016/j.ejmech.2012.03.019

Reference yield:

benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(2-tert-butyl-6-methoxyquinolin-8-yl)-amino]pentyl)amino)-6-oxohexyl]-carbamate (1267638-33-4) → N2,N6-bis[(benzyloxy)carbonyl]-D-lysyl-N6-[(benzyloxy)carbonyl]-N-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-lysinamide (1375013-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 0.75 h / 20 °C

2: diisopropyl-carbodiimide / dichloromethane / 20 °C / Cooling with ice

With hydrogenchloride; diisopropyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2012.03.019

Reference yield:

(R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid (55878-47-2) → N2,N6-bis[(benzyloxy)carbonyl]-D-lysyl-N6-[(benzyloxy)carbonyl]-N-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-lysinamide (1375013-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1: diisopropyl-carbodiimide / dichloromethane / 20 °C / Cooling with ice

2: hydrogenchloride / methanol / 0.75 h / 20 °C

3: diisopropyl-carbodiimide / dichloromethane / 20 °C / Cooling with ice

With hydrogenchloride; diisopropyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2012.03.019

upstream raw materials:

benzyl [(5R)-5-[(tert-butoxycarbonyl)amino]-6-((4-[(2-tert-butyl-6-methoxyquinolin-8-yl)-amino]pentyl)amino)-6-oxohexyl]-carbamate

benzyl ((5R)-5-amino-6-[(4-((2-tert-butyl-6-methoxyquinolin-8-yl)amino)pentyl)amino]-6-oxohexyl)carbamate

N^α,N^ε-Bis(benzyloxycarbonyl)-D-lysine

(R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid

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