(2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

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Chemical Name:(2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide
CAS No.:1448309-79-2
Molecular Formula:C₃₀H₃₁ClF₃N₅O₂
Molecular Weight:586.057
Hs Code.:

Synonyms:(2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

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Chemical Property of (2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

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Technology Process of (2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

There total 7 articles about (2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000698-98-5
1,1-difluoro-4-isocyanocyclohexane

: 1448310-19-7
(2S,5S)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxylic acid

: 1273566-51-0
C₆H₁₂FN

: 89-98-5
2-chloro-benzaldehyde

: 1448309-79-2
(2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

: 1448309-80-5
(2S,5S)-N-((S)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxo ethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

Guidance literature:: C₆H₁₂FN; 2-chloro-benzaldehyde; In methanol; at 20 ℃; for 0.5h;

(2S,5S)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxylic acid; In methanol; for 0.5h;

1,1-difluoro-4-isocyanocyclohexane; In methanol; at 20 ℃;

Reference yield:

: 144978-35-8,144978-12-1,251924-83-1
(S)-ethyl N-tert-butoxycarbonylpyroglutamate

: 1448309-79-2
(2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

: 1448309-80-5
(2S,5S)-N-((S)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxo ethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / -40 - 0 °C

2.1: dichloromethane / 3 h / 20 °C

3.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

5.1: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 20 °C

6.1: methanol / 0.5 h / 20 °C

6.2: 0.5 h

6.3: 20 °C

With palladium 10% on activated carbon; water; hydrogen; potassium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 6.1: |Ugi Condensation;

Reference yield:

: 913251-58-8
(S)-2-(tert-butoxycarbonylamino)-5-oxohexanoic acid ethyl ester

: 1448309-79-2
(2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

: 1448309-80-5
(2S,5S)-N-((S)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxo ethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 3 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

4.1: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 20 °C

5.1: methanol / 0.5 h / 20 °C

5.2: 0.5 h

5.3: 20 °C

With palladium 10% on activated carbon; water; hydrogen; potassium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 5.1: |Ugi Condensation;