1,1-difluoro-4-isocyanocyclohexane

Base Information

• Chemical Name: 1,1-difluoro-4-isocyanocyclohexane
• CAS No.: 1000698-98-5
• Molecular Formula: C₇H₉F₂N
• Molecular Weight: 145.152

Synonyms:1,1-difluoro-4-isocyanocyclohexane

Chemical Property of 1,1-difluoro-4-isocyanocyclohexane

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,1-Difluoro-4-isocyanocyclohexane ^*data from reagent suppliers

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Technology Process of 1,1-difluoro-4-isocyanocyclohexane

There total 10 articles about 1,1-difluoro-4-isocyanocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(4,4-difluorocyclohexyl)formamide (1448309-95-2) → 1,1-difluoro-4-isocyanocyclohexane (1000698-98-5)

Guidance literature:

With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

Reference yield: 86.0%

N-(4,4-difluorocyclohexyl)formamide (1448309-95-2) + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) → 1,1-difluoro-4-isocyanocyclohexane (1000698-98-5)

Guidance literature:

With triethylamine; triphenylphosphine; In tetrachloromethane; diethyl ether;

Reference yield:

4,4-difluorocyclohexylamine hydrochloride (675112-70-6) + chloroform (67-66-3,8013-54-5) → 1,1-difluoro-4-isocyanocyclohexane (1000698-98-5)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; at 20 ℃; for 72h;

upstream raw materials:

4,4-difluorocyclohexylamine hydrochloride

chloroform

N-(4,4-difluorocyclohexyl)formamide

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

Downstream raw materials:

C₃₂H₄₀ClF₂N₃O₄

(S)-N-(1-(2-chlorophenyl)-2-((4,4-difluorocyclohexyl)amino)-2-oxoethyl)-N-(3-fluoro-phenyl)-5-oxopyrrolidine-2-carboxamide

(2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

(2S,5S)-N-((S)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxo ethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide

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