Technology Process of C19H19NO2
There total 5 articles about C19H19NO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-pyridinecarboxylic acid ethyl ester; oxygen; palladium diacetate; sodium carbonate;
In
1,4-dioxane;
at 70 ℃;
for 27h;
under 760.051 Torr;
DOI:10.1021/ol2006083
- Guidance literature:
-
Multi-step reaction with 5 steps
1: propionic acid / 16 h / 140 °C / Dean-Stark trap; Inert atmosphere
2: water; potassium hydroxide / ethanol / 10 h / 20 °C
3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C
4: pyridine / dichloromethane / 12 h / 0 - 20 °C
5: 3-pyridinecarboxylic acid ethyl ester; oxygen; palladium diacetate; sodium carbonate / 1,4-dioxane / 27 h / 70 °C / 760.05 Torr
With
pyridine; 3-pyridinecarboxylic acid ethyl ester; oxalyl dichloride; water; oxygen; palladium diacetate; sodium carbonate; propionic acid; N,N-dimethyl-formamide; potassium hydroxide;
In
1,4-dioxane; ethanol; dichloromethane;
1: Johnson-Claisen rearrangement;
DOI:10.1021/ol2006083
- Guidance literature:
-
Multi-step reaction with 3 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C
2: pyridine / dichloromethane / 12 h / 0 - 20 °C
3: 3-pyridinecarboxylic acid ethyl ester; oxygen; palladium diacetate; sodium carbonate / 1,4-dioxane / 27 h / 70 °C / 760.05 Torr
With
pyridine; 3-pyridinecarboxylic acid ethyl ester; oxalyl dichloride; oxygen; palladium diacetate; sodium carbonate; N,N-dimethyl-formamide;
In
1,4-dioxane; dichloromethane;
DOI:10.1021/ol2006083
