1-(4-bromophenyl)-N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxamide

Base Information

Chemical Name:1-(4-bromophenyl)-N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxamide
CAS No.:1429186-15-1
Molecular Formula:C₂₅H₁₉BrCl₂N₂O₃
Molecular Weight:546.247
Hs Code.:

Synonyms:1-(4-bromophenyl)-N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxamide

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Chemical Property of 1-(4-bromophenyl)-N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxamide

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Technology Process of 1-(4-bromophenyl)-N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxamide

There total 6 articles about 1-(4-bromophenyl)-N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3-(3,4-dichlorophenyl)propan-1-amine hydrochloride

: 1429188-19-1
1-(4-bromophenyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carbonyl chloride

: 1429186-15-1
1-(4-bromophenyl)-N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1429187-63-2
tert-butyl 3-(3 ,4-dichlorophenyl)propylcarbamate

: 1429186-15-1
1-(4-bromophenyl)-N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 25173-68-6
3(3,4-dichlorophenyl)propanoic acid

: 1429186-15-1
1-(4-bromophenyl)-N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3.5 h / 0 - 20 °C

2: ammonium hydroxide / diethyl ether; water / 2.5 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 7.17 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 20 °C

5: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;