N,N-Dimethyl Sunitinib

Base Information

Chemical Name:N,N-Dimethyl Sunitinib
CAS No.:326914-17-4
Molecular Formula:C₂₀H₂₃FN₄O₂
Molecular Weight:370.427
Hs Code.:
Mol file:326914-17-4.mol

Synonyms:N,N-Dimethyl Sunitinib;N-[2-(Dimethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

Suppliers and Price of N,N-Dimethyl Sunitinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
N,N-DimethylSunitinib
1 mg
$ 900.00

Biosynth Carbosynth
N,N-Dimethyl sunitinib
10 mg
$ 3003.00

Biosynth Carbosynth
N,N-Dimethyl sunitinib
5 mg
$ 1651.70

Biosynth Carbosynth
N,N-Dimethyl sunitinib
2 mg
$ 908.50

Biosynth Carbosynth
N,N-Dimethyl sunitinib
1 mg
$ 499.70

American Custom Chemicals Corporation
N,N-DIMETHYL SUNITINIB 95.00%
10MG
$ 3118.50

American Custom Chemicals Corporation
N,N-DIMETHYL SUNITINIB 95.00%
1MG
$ 284.55

Total 7 raw suppliers

Chemical Property of N,N-Dimethyl Sunitinib

Chemical Property:

Vapor Pressure:2.51E-12mmHg at 25°C
Refractive Index:1.627
Boiling Point:554.3°C at 760 mmHg
PKA:11.70±0.20(Predicted)
Flash Point:289°C
PSA：77.23000
Density:1.272g/cm³
LogP:3.08360
Storage Temp.:Amber Vial, Refrigerator
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly)

Purity/Quality:

≥95% ^*data from raw suppliers

N,N-DimethylSunitinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Sunitinib (S820000) intermediate. Angiogenesis inhibitor and antitumor prodrug Sunitinib (S820000) intermediate. Angiogenesis inhibitor and antitumor prodrug. Sunitinib intermediate. Angiogenesis inhibitor and antitumor prodrug.

Technology Process of N,N-Dimethyl Sunitinib

There total 9 articles about N,N-Dimethyl Sunitinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1158560-66-7
(Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carbonyl chloride

: 108-00-9
N,N-dimethylethylenediamine

: 326914-17-4
(Z)-N-(2-(dimethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Guidance literature:: In tetrahydrofuran; at 20 - 50 ℃; for 1h;
DOI:10.1016/j.ejmech.2020.112316

Reference yield: 54.0%

: 326914-17-4
(Z)-N-(2-(dimethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Guidance literature:: In tetrahydrofuran; at 50 ℃; for 1h;

Reference yield:

: 108-00-9
N,N-dimethylethylenediamine

: 356068-93-4
5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

: 326914-17-4
(Z)-N-(2-(dimethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0204183