methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate

Base Information

Chemical Name:methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate
CAS No.:216988-59-9
Molecular Formula:C₁₅H₁₈INO₄S
Molecular Weight:435.283
Hs Code.:

Synonyms:methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate

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Chemical Property of methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate

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Technology Process of methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate

There total 5 articles about methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 216988-55-5
methyl 2-(4-tolylsulfonylamino)hept-4-ynoate

: 216988-59-9
methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate

Guidance literature:: With iodine; potassium carbonate; In acetonitrile; at 0 - 20 ℃; for 14h;
DOI:10.1039/a806386i

Reference yield:

: 16400-32-1
1-bromo-pent-2-yne

: 216988-59-9
methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 44 percent / K₂CO₃; Bu₄NI / acetonitrile / 7 h / Heating

2: 51 percent / aq. HCl / diethyl ether / 1 h

3: 72 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

4: 71 percent / K₂CO₃; I₂ / acetonitrile / 0 - 20 °C

With hydrogenchloride; dmap; iodine; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1039/b110751h

Reference yield:

: 441777-48-6
methyl 2-aminohept-4-ynoate

: 216988-59-9
methyl 5-ethyl-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

2: 71 percent / K₂CO₃; I₂ / acetonitrile / 0 - 20 °C

With dmap; iodine; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1039/b110751h