4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarbohydrazide

Base Information

Chemical Name:4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarbohydrazide
CAS No.:1094345-77-3
Molecular Formula:C₁₅H₂₃N₃O₄
Molecular Weight:309.365
Hs Code.:

Synonyms:4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarbohydrazide

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Chemical Property of 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarbohydrazide

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Technology Process of 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarbohydrazide

There total 1 articles about 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 1094345-77-3
4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarbohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,3-bis-(diphenylphosphino)propane; N-ethyl-N,N-diisopropylamine / palladium diacetate / dimethyl sulfoxide / 72 h / 75 °C / 3102.97 Torr / Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / 16.5 h / -7 - 20 °C

2.2: pH 12

3.1: caesium carbonate / 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate / toluene / 22 h / 85 °C / Inert atmosphere

4.1: ethanol / 4 h / Reflux

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium nitrite; 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate; In ethanol; water; dimethyl sulfoxide; toluene;

Reference yield:

: {4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetic acid

: 1094345-77-3
4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarbohydrazide

: 1094342-08-1
3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-4-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2.5 h / 20 °C

1.2: 20 °C

2.1: pyridinium p-toluenesulfonate / methanol / 8 h / 60 °C

With pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol;