(2S,3S)-ethyl 3-benzyl-2-((4-methoxyphenyl)amino)-4-oxobutanoate

Base Information

• Chemical Name: (2S,3S)-ethyl 3-benzyl-2-((4-methoxyphenyl)amino)-4-oxobutanoate
• CAS No.: 536761-14-5
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 536761-14-5.mol

Synonyms:(2S,3S)-ethyl 3-benzyl-2-((4-methoxyphenyl)amino)-4-oxobutanoate

Chemical Property of (2S,3S)-ethyl 3-benzyl-2-((4-methoxyphenyl)amino)-4-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-ethyl 3-benzyl-2-((4-methoxyphenyl)amino)-4-oxobutanoate

There total 3 articles about (2S,3S)-ethyl 3-benzyl-2-((4-methoxyphenyl)amino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-phenyl-propionaldehyde (104-53-0) + ethyl (4-methoxyphenylimino)acetate (124156-21-4) → (2S,3S)-ethyl 3-benzyl-2-((4-methoxyphenyl)amino)-4-oxobutanoate (536761-14-5)

Guidance literature:

3-phenyl-propionaldehyde; With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; L-proline; In neat (no solvent); at 25 ℃; for 0.166667h;

ethyl (4-methoxyphenylimino)acetate; In neat (no solvent); at 25 ℃; for 0.0833333h; Concentration; Time; stereoselective reaction;

DOI:10.1021/jo4019304

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + ethyl (E)-2-(p-methoxyphenylimino)acetate (115276-75-0,124156-21-4,120419-96-7) → (2S,3S)-ethyl 3-benzyl-2-((4-methoxyphenyl)amino)-4-oxobutanoate (536761-14-5) + (2R,3R)-3-Formyl-2-(4-methoxy-phenylamino)-4-phenyl-butyric acid ethyl ester + (2S,3R)-3-Formyl-2-(4-methoxy-phenylamino)-4-phenyl-butyric acid ethyl ester

Guidance literature:

With L-proline; In tetrahydrofuran; water; at 20 ℃; Title compound not separated from byproducts;

DOI:10.1016/S0040-4039(03)00019-4

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + ethyl (4-methoxyphenylimino)acetate (124156-21-4) → ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate (871797-58-9) + (2S,3S)-ethyl 3-benzyl-2-((4-methoxyphenyl)amino)-4-oxobutanoate (536761-14-5)

Guidance literature:

With N-(4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-2-yl)-C,C,C-trifluoro-methanesulfonamide; In 1,4-dioxane; at 20 ℃; for 4h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/chem.200900267

upstream raw materials:

3-phenyl-propionaldehyde

ethyl (4-methoxyphenylimino)acetate

ethyl (E)-2-(p-methoxyphenylimino)acetate