1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid (1-hydrazinocarbonyl-1-methyl-ethyl)-amide

Base Information

Chemical Name:1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid (1-hydrazinocarbonyl-1-methyl-ethyl)-amide
CAS No.:914292-46-9
Molecular Formula:C₁₉H₂₈N₄O₅
Molecular Weight:392.455
Hs Code.:

Synonyms:1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid (1-hydrazinocarbonyl-1-methyl-ethyl)-amide

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Chemical Property of 1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid (1-hydrazinocarbonyl-1-methyl-ethyl)-amide

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Technology Process of 1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid (1-hydrazinocarbonyl-1-methyl-ethyl)-amide

There total 5 articles about 1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid (1-hydrazinocarbonyl-1-methyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 914292-45-8
2-{[1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carbonyl]-amino}-2-methyl-propionic acid methyl ester

: 914292-46-9
1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid (1-hydrazinocarbonyl-1-methyl-ethyl)-amide

Guidance literature:: With hydrazine hydrate; In methanol; at 20 ℃;
DOI:10.1021/ja0647699

Reference yield:

: 914292-43-6
1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid benzyl ester

: 914292-46-9
1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid (1-hydrazinocarbonyl-1-methyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃; H₂ / Pd/C / ethanol

2: 64 percent / HBTU; 1-hydroxybenzotriazole hydrate; Et₃N / dimethylformamide / 1.5 h

3: 62 percent / N₂H₄*H₂O / methanol / 20 °C

With hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; triethylamine; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja0647699

Reference yield:

: 80089-24-3
benzyl prolinate hydrochloride

: 914292-46-9
1-(4-dimethoxymethyl-benzoyl)-pyrrolidine-2-carboxylic acid (1-hydrazinocarbonyl-1-methyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / HBTU; 1-hydroxybenzotriazole hydrate; Et₃N / dimethylformamide / 1.5 h

2: 89 percent / K₂CO₃; H₂ / Pd/C / ethanol

3: 64 percent / HBTU; 1-hydroxybenzotriazole hydrate; Et₃N / dimethylformamide / 1.5 h

4: 62 percent / N₂H₄*H₂O / methanol / 20 °C

With hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; triethylamine; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja0647699