1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane

Base Information

• Chemical Name: 1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane
• CAS No.: 883992-08-3
• Molecular Formula: C₄₄H₄₂ClNO₇
• Molecular Weight: 732.273
• Mol file: 883992-08-3.mol

Synonyms:1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane

Chemical Property of 1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane

There total 4 articles about 1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

1-{3-[1-(p-chlorobenzoyl-5-methoxy-2-methyl)-indolacetyl]}-imidazole (78436-46-1) + 10,10,10-triphenyl-3,6,9-trioxadecan-1-ol (133699-09-9) → 1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane (883992-08-3)

Guidance literature:

In tetrahydrofuran; for 24h;

DOI:10.1016/j.bmcl.2006.01.003

Reference yield:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → 1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane (883992-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h

2: 9 percent / tetrahydrofuran / 24 h

In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.01.003

Reference yield:

trityl chloride (76-83-5) → 1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane (883992-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / pyridine / 24 h / 45 °C

2: 9 percent / tetrahydrofuran / 24 h

In tetrahydrofuran; pyridine;

DOI:10.1016/j.bmcl.2006.01.003

upstream raw materials:

1-{3-[1-(p-chlorobenzoyl-5-methoxy-2-methyl)-indolacetyl]}-imidazole

10,10,10-triphenyl-3,6,9-trioxadecan-1-ol

trityl chloride

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Downstream raw materials:

[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethyl ester