indomethacin triethylene ester

Base Information

Chemical Name:indomethacin triethylene ester
CAS No.:157769-09-0
Molecular Formula:C₂₅H₂₈ClNO₇
Molecular Weight:489.953
Hs Code.:
Mol file:157769-09-0.mol

Synonyms:Triethyleneglycol indomethacin ester

Suppliers and Price of indomethacin triethylene ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
INDOMETHACIN TRIETHYLENE ESTER 95.00%
5MG
$ 498.65

Total 1 raw suppliers

Chemical Property of indomethacin triethylene ester

Chemical Property:

Vapor Pressure:7.55E-15mmHg at 25°C
Boiling Point:591.7°C at 760 mmHg
Flash Point:311.7°C
PSA：96.22000
Density:1.27g/cm³
LogP:3.41140

Purity/Quality:: INDOMETHACIN TRIETHYLENE ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of indomethacin triethylene ester

There total 6 articles about indomethacin triethylene ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 883992-08-3
1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetoxy]}-8-trityloxy-3,6-dioxaoctane

: 157769-09-0
[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h;
DOI:10.1016/j.bmcl.2006.01.003

Reference yield:

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

: 157769-09-0
[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h

2: 9 percent / tetrahydrofuran / 24 h

3: 64 percent / TFA / CH₂Cl₂ / 0.5 h

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2006.01.003

Reference yield:

: 78436-46-1
1-{3-[1-(p-chlorobenzoyl-5-methoxy-2-methyl)-indolacetyl]}-imidazole

: 157769-09-0
[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 9 percent / tetrahydrofuran / 24 h

2: 64 percent / TFA / CH₂Cl₂ / 0.5 h

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2006.01.003