Z-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one

Base Information

• Chemical Name: Z-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one
• CAS No.: 127117-33-3
• Molecular Formula: C₁₄H₁₃NO₄
• Molecular Weight: 259.262
• Mol file: 127117-33-3.mol

Synonyms:Z-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one

Chemical Property of Z-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one

There total 1 articles about Z-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.9%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + Acetol acetate (592-20-1) → E-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one (127117-32-2) + Z-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one (127117-33-3)

Guidance literature:

With lead acetate; acetic anhydride; In tetrahydrofuran; for 16h; Heating;

DOI:10.1016/S0040-4020(01)85125-5

Reference yield:

Z-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one (127117-33-3) → 4-(2-acetoxy-1-methyl-ethyl)-2-phenyl-4H-oxazol-5-one (412304-58-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane;

DOI:10.1021/jo01036a022

Reference yield:

Z-2-phenyl-4(2-acetoxy-1-methylethylidene)-2-oxazoline-5-one (127117-33-3) → Acetic acid (R)-2-((R)-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-propyl ester

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; for 5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85125-5

upstream raw materials:

Hippuric Acid

Acetol acetate

Downstream raw materials:

4-(2-acetoxy-1-methyl-ethyl)-2-phenyl-4H-oxazol-5-one