di-tert-butyl ((Z)-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate

Base Information

• Chemical Name: di-tert-butyl ((Z)-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate
• CAS No.: 1351438-85-1
• Molecular Formula: C₂₃H₃₅F₃N₄O₄
• Molecular Weight: 488.551
• Mol file: 1351438-85-1.mol

Synonyms:di-tert-butyl ((Z)-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate

Chemical Property of di-tert-butyl ((Z)-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl ((Z)-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate

There total 4 articles about di-tert-butyl ((Z)-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)aniline (1350816-40-8) + N,N'-bis-Boc-S-methyl-isothiourea (322474-21-5) → di-tert-butyl ((Z)-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate (1351438-85-1)

Guidance literature:

With mercury (II) chloride; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm2011172

Reference yield:

4-bromo-2-nitro-1-(trifluoromethyl)benzene (251115-21-6) → di-tert-butyl ((Z)-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate (1351438-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: hydrogen; palladium(II) hydroxide / methanol

3.1: mercury (II) chloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; palladium(II) hydroxide; mercury (II) chloride; triethylamine; In methanol; dichloromethane; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;

DOI:10.1021/jm2011172

Reference yield:

N,N-Dimethylpropargylamin (7223-38-3) → di-tert-butyl ((Z)-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate (1351438-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: hydrogen; palladium(II) hydroxide / methanol

3.1: mercury (II) chloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; palladium(II) hydroxide; mercury (II) chloride; triethylamine; In methanol; dichloromethane; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;

DOI:10.1021/jm2011172

upstream raw materials:

N,N-Dimethylpropargylamin

4-bromo-2-nitro-1-(trifluoromethyl)benzene

C₁₂H₁₁F₃N₂O₂

5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)aniline

Downstream raw materials:

9-chloro-2-{[5-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one

9-chloro-2-(5-(3-(dimethylamino)propyl)-2-(trifluoromethyl)phenylamino)-5H-benzo[b]pyrimido[4,5-d]azepine-6(7H)-thione

Refernces