4'-(3'',5''-di-O-acetyl-2''-deoxy-β-D-ribofuranosyl)-3,4-dimethoxybiphenyl

Base Information

Chemical Name:4'-(3'',5''-di-O-acetyl-2''-deoxy-β-D-ribofuranosyl)-3,4-dimethoxybiphenyl
CAS No.:912818-38-3
Molecular Formula:C₂₃H₂₆O₇
Molecular Weight:414.455
Hs Code.:

Synonyms:4'-(3'',5''-di-O-acetyl-2''-deoxy-β-D-ribofuranosyl)-3,4-dimethoxybiphenyl

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Chemical Property of 4'-(3'',5''-di-O-acetyl-2''-deoxy-β-D-ribofuranosyl)-3,4-dimethoxybiphenyl

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Technology Process of 4'-(3'',5''-di-O-acetyl-2''-deoxy-β-D-ribofuranosyl)-3,4-dimethoxybiphenyl

There total 7 articles about 4'-(3'',5''-di-O-acetyl-2''-deoxy-β-D-ribofuranosyl)-3,4-dimethoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 912818-31-6
4-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)-1-bromobenzene

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 912818-38-3
4'-(3'',5''-di-O-acetyl-2''-deoxy-β-D-ribofuranosyl)-3,4-dimethoxybiphenyl

Guidance literature:: With potassium fluoride; johnphos; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2006.05.072

Reference yield:

: 898828-50-7
4-(2'-deoxy-β-D-ribofuranosyl)-1-bromobenzene

: 912818-38-3
4'-(3'',5''-di-O-acetyl-2''-deoxy-β-D-ribofuranosyl)-3,4-dimethoxybiphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / 4-(dimethylamino)pyridine; pyridine / 16 h / 20 °C

2: 93 percent / KF; 2-(di-tert-butylphosphino)biphenyl / Pd(OAc)2 / tetrahydrofuran / 16 h / 20 °C

With pyridine; dmap; potassium fluoride; johnphos; palladium diacetate; In tetrahydrofuran; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.05.072

Reference yield:

: 912818-30-5
{{(2R,3S,5R)-5-(4-bromophenyl)-2-{[(tert-butyldimethylsilyl)oxy]methyl}tetrahydrofuran-3-yl}oxy}(tert-butyl)dimethylsilane

: 912818-38-3
4'-(3'',5''-di-O-acetyl-2''-deoxy-β-D-ribofuranosyl)-3,4-dimethoxybiphenyl

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / acetic acid; tert-butylammonium fluoride / tetrahydrofuran / -10 - 20 °C

2: 99 percent / 4-(dimethylamino)pyridine; pyridine / 16 h / 20 °C

3: 93 percent / KF; 2-(di-tert-butylphosphino)biphenyl / Pd(OAc)2 / tetrahydrofuran / 16 h / 20 °C

With pyridine; dmap; potassium fluoride; tert-butyl-ammonium fluoride; acetic acid; johnphos; palladium diacetate; In tetrahydrofuran; 3: Suzuki coupling;
DOI:10.1016/j.bmc.2006.05.072