Technology Process of N-(4-isopropylphenyl)-2-(4,6,6-trimethyl-2-oxomorpholin-3-yl)acetamide
There total 5 articles about N-(4-isopropylphenyl)-2-(4,6,6-trimethyl-2-oxomorpholin-3-yl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
formaldehyd; 2-(6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide;
In
tetrahydrofuran; water; acetonitrile;
at 20 ℃;
for 0.25h;
With
sodium cyanoborohydride;
In
tetrahydrofuran; water; acetonitrile;
for 0.25h;
With
acetic acid;
In
tetrahydrofuran; water; acetonitrile;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / palladium 10% on activated carbon / acetic acid methyl ester / 5 h / 20 °C
2: sodium cyanoborohydride; acetic acid / acetonitrile; water; tetrahydrofuran / 20 °C
With
hydrogen; sodium cyanoborohydride; acetic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; acetic acid methyl ester; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran; ethylbenzene / 1 h / -70 °C
1.2: 70 °C
2.1: trifluoroacetic acid / dichloromethane / 20 °C
3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 0.5 h / 20 °C
3.2: 20 °C
4.1: palladium 10% on activated carbon; hydrogen / acetic acid methyl ester / 5 h / 20 °C
5.1: sodium cyanoborohydride / water; tetrahydrofuran; acetonitrile / 0.25 h / 20 °C
5.2: 1 h / 20 °C
With
palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; acetic acid methyl ester; ethylbenzene; water; acetonitrile;
DOI:10.1021/jm501814x
