tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-{{(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}sulfonyl}glycinate

Base Information

Chemical Name:tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-{{(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}sulfonyl}glycinate
CAS No.:1057340-19-8
Molecular Formula:C₂₉H₄₃IN₂O₇SSi
Molecular Weight:718.726
Hs Code.:

Synonyms:tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-{{(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}sulfonyl}glycinate

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Chemical Property of tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-{{(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}sulfonyl}glycinate

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Technology Process of tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-{{(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}sulfonyl}glycinate

There total 6 articles about tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-{{(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}sulfonyl}glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1057340-18-7
N-(t-butoxycarbonylsulfamoyl)-N-(2-benzyloxy-4-iodophenyl)glycine tert-butyl ester

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 1057340-19-8
tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-{{(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}sulfonyl}glycinate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; for 19h;

Reference yield:

: 27783-55-7
5-iodo-2-nitrophenol

: 1057340-19-8
tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-{{(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}sulfonyl}glycinate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 65 °C

2: iron; acetic acid / ethanol / 1.5 h / 100 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

4: triethylamine / dichloromethane / 0.5 h / 0 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 19 h

With di-isopropyl azodicarboxylate; iron; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1057340-17-6
2-benzyloxy-4-iodo-1-nitrobenzene

: 1057340-19-8
tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-{{(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}sulfonyl}glycinate

Guidance literature:: Multi-step reaction with 4 steps

1: iron; acetic acid / ethanol / 1.5 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

3: triethylamine / dichloromethane / 0.5 h / 0 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 19 h

With di-isopropyl azodicarboxylate; iron; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;