1-[4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenoxy]-3-methylcyclopentane carboxylic acid

Base Information

Chemical Name:1-[4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenoxy]-3-methylcyclopentane carboxylic acid
CAS No.:321853-33-2
Molecular Formula:C₂₂H₂₄ClNO₄
Molecular Weight:401.89
Hs Code.:

Synonyms:1-[4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenoxy]-3-methylcyclopentane carboxylic acid

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Chemical Property of 1-[4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenoxy]-3-methylcyclopentane carboxylic acid

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Technology Process of 1-[4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenoxy]-3-methylcyclopentane carboxylic acid

There total 6 articles about 1-[4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenoxy]-3-methylcyclopentane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1757-42-2,6195-92-2
3-methyl-cyclopentanone

: 67-66-3,8013-54-5
chloroform

: 321853-32-1
4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenol

: 321853-33-2
1-[4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenoxy]-3-methylcyclopentane carboxylic acid

Guidance literature:: 4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenol; With sodium hydroxide; In tetrahydrofuran; for 0.25h;

3-methyl-cyclopentanone; chloroform; In tetrahydrofuran; at 0 - 20 ℃; Further stages.;
DOI:10.1021/jm000199q

Reference yield:

: 16582-38-0
3-chloro-5-nitrotoluene

: 321853-33-2
1-[4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenoxy]-3-methylcyclopentane carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 93 percent / tin(II) chloride dihydrate / ethanol / 3 h / Heating

2.1: 58 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

3.1: sodium hydroxide / tetrahydrofuran / 0.25 h

3.2: 26 percent / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm000199q

Reference yield:

: 5465-33-8
2-chloro-4-methyl-6-nitroaniline

: 321853-33-2
1-[4-[[(3-chloro-5-methylanilino)carbonyl]methyl]phenoxy]-3-methylcyclopentane carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; aq. sodium nitrite / ethanol / 0.5 h / 0 - 20 °C

1.2: 69 percent / ethanol; H₂O / Heating

2.1: 93 percent / tin(II) chloride dihydrate / ethanol / 3 h / Heating

3.1: 58 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

4.1: sodium hydroxide / tetrahydrofuran / 0.25 h

4.2: 26 percent / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; sulfuric acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm000199q