dimethyl sulfamic acid 5-(1-methyl-1H-indol-2-yl)pyridin-3-yl ester

Base Information

• Chemical Name: dimethyl sulfamic acid 5-(1-methyl-1H-indol-2-yl)pyridin-3-yl ester
• CAS No.: 1202551-97-0
• Molecular Formula: C₁₆H₁₇N₃O₃S
• Molecular Weight: 331.395
• Mol file: 1202551-97-0.mol

Synonyms:dimethyl sulfamic acid 5-(1-methyl-1H-indol-2-yl)pyridin-3-yl ester

Chemical Property of dimethyl sulfamic acid 5-(1-methyl-1H-indol-2-yl)pyridin-3-yl ester

Chemical Property:

Purity/Quality:

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Technology Process of dimethyl sulfamic acid 5-(1-methyl-1H-indol-2-yl)pyridin-3-yl ester

There total 1 articles about dimethyl sulfamic acid 5-(1-methyl-1H-indol-2-yl)pyridin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromopyridine-3-ol (74115-13-2) → dimethyl sulfamic acid 5-(1-methyl-1H-indol-2-yl)pyridin-3-yl ester (1202551-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate / acetone / 2 h / 0 °C

2: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1 h / 85 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In acetone; toluene; 2: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.5b01545

upstream raw materials:

5-bromopyridine-3-ol