(E)-methyl 5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoate

Base Information

Chemical Name:(E)-methyl 5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoate
CAS No.:945965-66-2
Molecular Formula:C₃₂H₅₄O₅Sn
Molecular Weight:637.488
Hs Code.:

Synonyms:(E)-methyl 5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoate

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Chemical Property of (E)-methyl 5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoate

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Technology Process of (E)-methyl 5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoate

There total 4 articles about (E)-methyl 5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 945965-65-1
methyl 5-(5-tert-butoxycarbonyl-pent-1-ynyl)-2-methoxy-3-methylbenzoate

: 688-73-3
tri-n-butyl-tin hydride

: 945965-66-2
(E)-methyl 5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 53293-00-8
hex-5-ynoic acid

: 945965-66-2
(E)-methyl 5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / tert-butyl alcohol / 2 h / 20 °C

2: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 20 °C

With dmap; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tert-butyl alcohol; 2: Sonogashira Coupling;

Reference yield:

: 6082-99-1
5-iodo-2-methoxy-3-methylbenzoic acid methyl ester

: 945965-66-2
(E)-methyl 5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1: Sonogashira Coupling;