1-methyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde

Base Information

Chemical Name:1-methyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde
CAS No.:554408-75-2
Molecular Formula:C₁₆H₂₂O₂
Molecular Weight:246.349
Hs Code.:

Synonyms:1-methyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde

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Chemical Property of 1-methyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde

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Technology Process of 1-methyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde

There total 8 articles about 1-methyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 554408-74-1
2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde

: 74-88-4
methyl iodide

: 554408-75-2
1-methyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde

Guidance literature:: 2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde; With sodium hydride; In 1,2-dimethoxyethane; hexane; at 0 ℃; for 0.5h;

methyl iodide; In 1,2-dimethoxyethane; hexane; at 0 - 20 ℃; for 19h;
DOI:10.1016/S0040-4020(03)00236-9

Reference yield:

: 554408-79-6
[2-(4-methoxy-3-methyl-phenyl)-2-methyl-cyclopentyl]-methanol

: 554408-75-2
1-methyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / pyridinium chlorochromate / CH₂Cl₂

2.1: NaH / hexane; 1,2-dimethoxy-ethane / 0.5 h / 0 °C

2.2: 65 percent / hexane; 1,2-dimethoxy-ethane / 19 h / 0 - 20 °C

With sodium hydride; pyridinium chlorochromate; In 1,2-dimethoxyethane; hexane; dichloromethane;
DOI:10.1016/S0040-4020(03)00236-9

Reference yield:

: 554408-71-8
3-hydroxymethyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentanol

: 554408-75-2
1-methyl-2-(4-methoxy-3-methylphenyl)-2-methylcyclopentane-1-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: 84 percent / Et₃N; DMAP / CH₂Cl₂ / 0 °C

2.1: NaH / tetrahydrofuran / 3 h / 20 °C

2.2: tetrahydrofuran / 3 h / 20 °C

2.3: 86 percent / tetrahydrofuran / 16 h / 20 °C

3.1: 83 percent / AIBN; tri-n-butyltin hydride / toluene / 3 h / Heating

4.1: 92 percent / LiAlH₄ / tetrahydrofuran / 20 °C

5.1: 86 percent / pyridinium chlorochromate / CH₂Cl₂

6.1: NaH / hexane; 1,2-dimethoxy-ethane / 0.5 h / 0 °C

6.2: 65 percent / hexane; 1,2-dimethoxy-ethane / 19 h / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; toluene;
DOI:10.1016/S0040-4020(03)00236-9