3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid

Base Information

Chemical Name:3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid
CAS No.:1412438-71-1
Molecular Formula:C₂₇H₃₂N₆O₄
Molecular Weight:504.589
Hs Code.:

3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid

Synonyms:3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid

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Chemical Property of 3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid

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Technology Process of 3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid

There total 7 articles about 3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1412438-58-4
3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid

: 1412438-71-1
3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 4h;

Reference yield:

: 76006-33-2
3-bromo-2-methylbenzoic acid

: 1412438-71-1
3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium chloride / N,N-dimethyl-formamide / 20 °C

2.1: dimethylsulfide borane complex / Reflux

2.2: 0.17 h / 20 °C

2.3: 1 h / 20 °C

3.1: triethylamine / ethanol / 20 °C

4.1: N,N-dimethyl-formamide / 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate; water / 4 h / 20 °C

With hydrogenchloride; dimethylsulfide borane complex; sodium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 943722-20-1
[(3-bromo-2-methylphenyl)methyl]amine hydrochloride

: 1412438-71-1
3'-[(4-{[trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-5-nitro-pyrimidin-2-ylamino)-methyl]-2'-methyl-biphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethanol / 20 °C

2: N,N-dimethyl-formamide / 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

4: hydrogenchloride / ethyl acetate; water / 4 h / 20 °C

With hydrogenchloride; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;