3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide

Base Information

Chemical Name:3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide
CAS No.:878061-34-8
Molecular Formula:C₂₅H₂₄N₂O₃S
Molecular Weight:432.543
Hs Code.:

Synonyms:3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide

Suppliers and Price of 3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide

Chemical Property:

Boiling Point:690.7±55.0 °C(Predicted)
Density:1.20±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

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Technology Process of 3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide

There total 6 articles about 3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346559-95-2
3-benzylsulfonylindol-1-yl-acetic acid

: 103-67-3
benzyl-methyl-amine

: 878061-34-8
3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide

Guidance literature:: 3-benzylsulfonylindol-1-yl-acetic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

benzyl-methyl-amine; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 120-72-9
indole

: 878061-34-8
3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium iodide; thiourea; iodine / water; methanol / 2 h / 20 °C

1.2: 0.5 h / 85 °C

1.3: 20 °C

2.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h

2.2: 0.17 h / 20 °C

3.1: sodium hydrogencarbonate; Oxone / water; acetone / 18 h

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

4.2: 5 h

5.1: sodium hydroxide; water / methanol / 2 h / 20 °C

6.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 72 h / 20 °C

With Oxone; water; iodine; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; thiourea; potassium iodide; sodium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 633291-96-0
3-(benzylsulfanyl)-1H-indole

: 878061-34-8
3-(benzylsulfonyl)-N-benzyl-N-methyl-indole-1-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate; Oxone / water; acetone / 18 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

2.2: 5 h

3.1: sodium hydroxide; water / methanol / 2 h / 20 °C

4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 72 h / 20 °C

With Oxone; water; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetone; mineral oil;