(R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate
CAS No.:1364890-52-7
Molecular Formula:C₁₉H₂₅F₃N₂O₃
Molecular Weight:386.414
Hs Code.:

Synonyms:(R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

There total 11 articles about (R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364890-51-6
(R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4,4-difluoro-pyrrolidine-1-carboxylate

: 75-31-0
isopropylamine

: 13939-06-5,199620-15-0
molybdenum hexacarbonyl

: 1364890-52-7
(R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; trans-di(μ-acetato)-bis[-o-(di-o-tolylphosphino)benzyl]dipalladium(II); In tetrahydrofuran; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1364890-51-6
(R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4,4-difluoro-pyrrolidine-1-carboxylate

: 75-31-0
isopropylamine

: 1364890-52-7
(R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; molybdenum hexacarbonyl; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); In tetrahydrofuran; at 150 ℃; for 0.5h; Inert atmosphere; Microwave;

Reference yield:

: 94569-84-3
2-bromo-5-fluorobenzaldehyde

: 1364890-52-7
(R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 20 °C

2.1: sodium bromide; indium / water / 36 h

3.1: hydrogenchloride / methanol / 0.75 h / 20 °C

3.2: 0 °C

4.1: dichloromethane / 2 h / 0 °C

5.1: iodine / water; tetrahydrofuran / 6 h

6.1: sodium hydroxide / water; tetrahydrofuran / 3 h / pH 9

7.1: sodium hydroxide; methanol / 0 - 20 °C

8.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / -10 - 20 °C

9.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

10.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / trans-di(μ-acetato)-bis[-o-(di-o-tolylphosphino)benzyl]dipalladium(II) / tetrahydrofuran / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; indium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium bromide; sodium hydroxide; trans-di(μ-acetato)-bis[-o-(di-o-tolylphosphino)benzyl]dipalladium(II); In tetrahydrofuran; methanol; dichloromethane; water;