3-benzyloxy-2-(S)-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-1-propanol

Base Information

Chemical Name:3-benzyloxy-2-(S)-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-1-propanol
CAS No.:514829-77-7
Molecular Formula:C₂₂H₂₅FN₂O₃
Molecular Weight:384.451
Hs Code.:

Synonyms:3-benzyloxy-2-(S)-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-1-propanol

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Chemical Property of 3-benzyloxy-2-(S)-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-1-propanol

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Technology Process of 3-benzyloxy-2-(S)-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-1-propanol

There total 13 articles about 3-benzyloxy-2-(S)-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2930-05-4,14618-80-5,89616-40-0,16495-13-9
(S)-benzyl glycidyl ether

: 84163-77-9
6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole

: 514829-77-7
3-benzyloxy-2-(S)-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-1-propanol

Guidance literature:: In ethanol; for 18h; Reflux;
DOI:10.1021/op200310y

Reference yield: 93.5%

: methyl 2-(3-benzyloxy-2S-[4-fluorobenzo[d]isoxazol-3-yl]piperidin-1-yl)-propionate

: 514829-77-7
3-benzyloxy-2-(S)-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-1-propanol

Guidance literature:: With lithiumaluminum hydride bis(tetrahydrofuran); In toluene; at -2 - 15 ℃; Large scale;
DOI:10.1021/op020225p

Reference yield:

: 84163-43-9
1-formylisonipecotoyl chloride

: 514829-77-7
3-benzyloxy-2-(S)-[4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-1-propanol

Guidance literature:: Multi-step reaction with 7 steps

1: aluminum (III) chloride

2: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water

3: potassium hydroxide / isopropyl alcohol; water

4: hydrogenchloride

5: sodium hydroxide / dichloromethane / Large scale

6: toluene / 10 - 17 °C

7: lithiumaluminum hydride bis(tetrahydrofuran) / toluene / -2 - 15 °C / Large scale

With hydrogenchloride; aluminum (III) chloride; lithiumaluminum hydride bis(tetrahydrofuran); hydroxylamine hydrochloride; potassium hydroxide; sodium hydroxide; In dichloromethane; water; isopropyl alcohol; toluene;
DOI:10.1021/op020225p