(αS)-α-[(1S)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol

Base Information

• Chemical Name: (αS)-α-[(1S)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol
• CAS No.: 887307-58-6
• Molecular Formula: C₁₉H₂₂O₂S
• Molecular Weight: 314.448
• Mol file: 887307-58-6.mol

Synonyms:(αS)-α-[(1S)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol

Chemical Property of (αS)-α-[(1S)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (αS)-α-[(1S)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol

There total 1 articles about (αS)-α-[(1S)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diiodomethane (75-11-6) + benzaldehyde (100-52-7) + (R)-ethynyl-p-tolyl-sulfoxide (99930-83-3) → (αR)-α-[(1R)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol + (αS)-α-[(1S)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol (887307-58-6)

Guidance literature:

Multistep reaction. Title compound not separated from byproducts;

DOI:10.1021/ja060498q

Reference yield: 85.0%

(αS)-α-[(1S)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol (887307-58-6) → (1S,2S)-2-Ethyl-1-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ol

Guidance literature:

With Oxone; In methanol; water; for 6h;

DOI:10.1021/ja060498q

Reference yield:

(αS)-α-[(1S)-1-ethyl-2-[(S)-(4-methylphenyl)sulfinyl]-2-propenyl]-benzenemethanol (887307-58-6) → (2S,3S,4S)-3-Ethyl-2-phenyl-4-(toluene-4-sulfonyl)-tetrahydro-furan

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / oxone / methanol; H₂O / 6 h

2: 90 percent / KH / tetrahydrofuran / 2 h / 25 °C

With Oxone; potassium hydride; In tetrahydrofuran; methanol; water;

DOI:10.1021/ja060498q

upstream raw materials:

diiodomethane

benzaldehyde

(R)-ethynyl-p-tolyl-sulfoxide