(S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid
• CAS No.: 78395-33-2
• Molecular Formula: C₃₀H₄₆N₄O₈
• Molecular Weight: 590.717
• Mol file: 78395-33-2.mol

Synonyms:(S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid

Chemical Property of (S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid

There total 1 articles about (S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

H-Lys(Z)-Pro-OH trifluoroacetate (72172-50-0) + N-[(1,1-dimethylethoxy)carbonyl]-L-leucine pentafluorophenyl ester (50903-50-9) → (S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid (78395-33-2)

Guidance literature:

With 4-methyl-morpholine; In 1,4-dioxane; at 25 ℃; for 20h;

Reference yield: 67.0%

H-Leu-Glu(OBzl)-Glu(OBzl)-Val-Leu-Asn-Leu-OMe trifluoroacetate + (S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid (78395-33-2) → Boc-Leu-Lys(Z)-Pro-Leu-Glu(OBzl)-Glu(OBzl)-Val-Leu-Asn-Leu-OMe

Guidance literature:

With 4-methyl-morpholine; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 62h;

Reference yield:

trifluoroacetic acid (76-05-1) + (S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid (78395-33-2) → (S)-1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-6-benzyloxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid; compound with trifluoro-acetic acid

Guidance literature:

With acetic acid; at 10 - 20 ℃; for 0.5h;

upstream raw materials:

H-Lys(Z)-Pro-OH trifluoroacetate

N-[(1,1-dimethylethoxy)carbonyl]-L-leucine pentafluorophenyl ester