50903-50-9

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 61-90-5 L-leucine 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 439912-32-0 propargyl pentafluorophenyl carbonate 
• 244633-31-6 pentafluorophenyl 4-nitrobenzenesulfonate 

Downstream Products

• 114646-30-9 Boc-Leu-D-Asu-Phe-NH₂ 
• 114646-30-9 Boc-Leu-Asu-Phe-NH₂ 
• 78395-33-2 (S)-1-[(S)-6-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoyl]-pyrrolidine-2-carboxylic acid 
• 917253-25-9 S-2,2-dimethyl-3-(N-(1,1-dimethylethoxycarbonyl)-L-leucyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide 
• 78058-33-0 Z-pGlu-Leu-Pro-NH-Et 
• 78082-35-6 Z-pGlu-Leu-Pro-NH-DMAE 
• 78058-36-3 Z-pGlu-Leu-Pro-NH-Dec 
• 49760-92-1 pGlu-Leu-Pro-NH2 
• 78664-75-2 N-(benzyloxycarbonyl)-D-pyroglutamyl-L-leucyl-L-prolinamide 
• 78664-39-8 Z-pGlu-Leu-D-Pro-NH₂ 
• 88888-69-1 Z-pGlu-Leu-Pro-NH₂ 
• 917253-23-7 pentafluorophenyl S-2,2-dimethyl-3-(N-(1,1-dimethylethoxycarbonyl)-L-leucyl)tetrahydrothiazole-4-carboxylate 
• 431062-33-8 Tsoc-Leu-OPfp 

Relevant academic research and scientific papers

Combination of silyl carbamate and amino acid fluoride for solid-phase peptide synthesis

Diketopiperadine (DKP) formation is an often encountered side reaction in the synthesis of peptide having C-terminal proline ester. A novel strategy for the avoidance of this side reaction was developed, which utilizes Pfp ester of Tsoc-amino acid and Fmo

MULTI-TARGETED UBENIMEX PRODRUG DERIVATIVE AND PREPARATION METHOD AND USE THEREOF

The present invention relates to the design, synthesis, and biological study of multi-targeted Ubenimex pro-drug derivative. More particularly, provided in the present invention is a compound as shown by general structural formula (I) (wherein the definit

Simultaneous protection and activation of amino acids using propargyl pentafluorophenyl carbonate

A very efficient method for the simultaneous protection of the amino group and activation of the carboxyl group of amino acids is reported using propargyl pentafluorophenyl carbonate (PocOPfp). The amino group is protected as a propargyloxycarbonyl (Poc) derivative, and the carboxyl group is activated as a pentafluorophenyl ester. The yields obtained are good to excellent ranging from 60 to 87%.

Effects of steric bulk and stereochemistry on the rates of?diketopiperazine formation from N-aminoacyl-2,2-dimethylthiazolidine-4-carboxamides (Dmt dipeptide amides)-a model for a new prodrug linker system

A peptide-like self-immolative molecular clip is required for release of active drugs from prodrugs by endopeptidases. Upon cleavage from the carrier, this clip must collapse and release the drug rapidly. A series of aminoacyl-5,5-dimethylthiaproline (Aaa

Synthesis, Degradation, and Antimicrobial Properties of Targeted Macromolecular Prodrugs of Norfloxacin

Long-term antibiotic treatment is required to cure tuberculosis. Targeted antibiotics should improve the efficacy of treatment by concentrating the drugs close to the bacteria. The aim of the present study was to synthesize targeted conjugates. For this purpose, we used mannose as a homing device to direct norfloxacin into macrophages. Dextran was used as the polymer bearing both mannose and norfloxacin. Using different peptide spacer arms to link norfloxacin to dextran, we demonstrated that norfloxacin acts as an antibiotic only when it is released in its native form. Also, targeting by using mannose as a homing device is required to achieve antimycobacterial activity in vivo. Thus, norfloxacin, which is inactive against mycobacteria in its native form in vivo, can be transformed into an active drug by targeting.

Synthesis of aryl esters of protected amino acids from aryl sulfonates

Aryl esters of Boc- and Fmoc-protected amino acids derived from electron-deficient phenols have been prepared in good yields from aryl 4- nitrobenzenesulfonates in the presence of 1-hydroxy-benzotriazole as catalyst.