5-Isoquinolinamine,8-methoxy-(9CI)

Base Information

• Chemical Name: 5-Isoquinolinamine,8-methoxy-(9CI)
• CAS No.: 321921-99-7
• Molecular Formula: C10H10 N2 O
• Molecular Weight: 174.2
• Mol file: 321921-99-7.mol

Synonyms:8-Methoxyisoquinolin-5-amine

Chemical Property of 5-Isoquinolinamine,8-methoxy-(9CI)

Chemical Property:

• PSA: 48.14000
• LogP: 2.40680
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

8-Methoxyisoquinolin-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Isoquinolinamine,8-methoxy-(9CI)

There total 3 articles about 5-Isoquinolinamine,8-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-methoxy-7-nitro-isoquinoline (1380333-59-4) + 8-methoxy-5-nitrosoisoquinoline (156901-55-2) → 8-methoxy-isoquin-7-ylamine (648420-74-0) + 8-methoxy-isoquin-5-ylamine (321921-99-7)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethanol; for 3h; under 2585.81 Torr;

Reference yield:

8-methoxy-5-nitrosoisoquinoline (156901-55-2) → 8-methoxy-isoquin-5-ylamine (321921-99-7)

Guidance literature:

With hydrazine; nickel; In ethanol; water; for 2h; Heating;

DOI:10.1002/jhet.5570370545

Reference yield:

8-methoxyisoquinoline (1723-70-2) → 8-methoxy-isoquin-5-ylamine (321921-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 25.2 percent / conc. H₂SO₄; potassium nitrite / 1 h / -5 - 0 °C

2: hydrazine / Raney-nickel / ethanol; H₂O / 2 h / Heating

With potassium nitrite; sulfuric acid; hydrazine; nickel; In ethanol; water;

DOI:10.1002/jhet.5570370545

upstream raw materials:

8-methoxy-5-nitrosoisoquinoline

8-methoxyisoquinoline

8-methoxy-7-nitro-isoquinoline