1723-70-2

Basic information

• Product Name: 8-Methoxyisoquinoline
• Synonyms: 8-Methoxyisoquinoline;Isoquinoline, 8-methoxy- (7CI,8CI,9CI);8-Methoxyisoquinoline 96%;Isoquinoline,8-Methoxy-;8-Methoxy-2-azanaphthalene;8-Methoxyisoquinoline96%
• CAS NO: 1723-70-2
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18456
• EINECS: -0
• Product Categories: ISOQUINOLINE;blocks;Heterocycles;Quinolines;Quinoline&Isoquinoline
• Mol File: 1723-70-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 48-51 °C(Solv: ethyl ether (60-29-7); pentane (109-66-0))
• Boiling Point: 295.593 °C at 760 mmHg
• Flash Point: 108.428 °C
• Appearance: /
• Density: 1.131 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.611
• PKA: 5.55±0.23(Predicted)
• CAS DataBase Reference: 8-Methoxyisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methoxyisoquinoline(1723-70-2)
• EPA Substance Registry System: 8-Methoxyisoquinoline(1723-70-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1723-70-2(Hazardous Substances Data)

Usage

Uses

8-?Methoxyisoquinoline is a reagent used in the synthesis and binding studies for SK Channel blockers related to N-methyllaudanosine and N-methylnoscapine.

InChI:InChI=1/C10H9NO/c1-12-10-4-2-3-8-5-6-11-7-9(8)10/h2-7H,1H3

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 22483-09-6 2,2-dimethoxyethylamine 
• 81625-30-1 2-(ethoxycarbonyl)-3-methoxybenzyl chloride 
• 81625-29-8 N,N-dimethyl-2-(ethoxycarbonyl)-3-methoxybenzylamine 
• 81625-32-3 2-(2-Amino-ethyl)-6-methoxy-benzoic acid ethyl ester 
• 81625-31-2 2-(ethoxycarbonyl)-3-methoxyphenylacetonitrile 
• 15184-99-3 N,N-dimethyl-3-methoxybenzylamine 
• 74904-29-3 8-methoxy-3,4-dihydroisoquinolin-1(2H)-one 
• 344560-09-4 (2,2-Dimethoxy-ethyl)-[1-(2-methoxy-phenyl)-meth-(E)-ylidene]-amine 
• 344578-07-0 [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester 
• 34146-68-4 8-methoxy-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 863290-46-4 2-benzoyl-1-cyano-8-methoxy-1,2-dihydroisoquinoline 
• 129959-18-8 1-Benzoyl-8-methoxy-2-methylisoquinolinium iodide 
• 129959-24-6 3,3-Dimethyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinolinium iodide 
• 129959-22-4 1-(α-Bromobenzyl)-8-hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 129959-16-6 8-Methoxy-1-<2-(4'-methoxyphenyl)-1,3-dithiane-2-yl>-isoquinoline 
• 129959-13-3 8-Methoxy-1-(2-phenyl-1,3-dithiane-2-yl)-isoquinoline 
• 129959-20-2 1-(α-Hydroxybenzyl)-8-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 129959-19-9 1-Benzoyl-8-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 129959-23-5 3-Methyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinoline 
• 129959-17-7 1-Benzoyl-8-methoxyisoquinoline 
• 129959-06-4 1-Chloro-8-methoxyisoquinoline 
• 321921-99-7 8-methoxy-isoquin-5-ylamine 
• 863290-54-4 1-(3,4-dimethoxy-benzyl)-8-methoxy-isoquinoline 
• 3482-14-2 isoquinolin-8-ol 

Relevant articles and documents

AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS

Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents wherein: X is -N- or -CH-; n is from 0 to 3.

Studies on anti-Helicobacter pylori agents. Part 1: Benzyloxyisoquinoline derivatives

The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives that was discovered by a random screening process, are described. In the in vitro assay, compound 10c containing a 3-acetamido-2,6-dichlorobenzyl substituent was found to have extremely potent activity against H. pylori and no activity against other common bacteria. The anti-H. pylori activity of 10c was superior to that of amoxicillin (AMPC) (1) and clarithromycin (CAM) (2). However, 10c did not show in vivo efficacy in a mouse infection model; a feature attributed to the lack of strong bactericidal activity at short contact times. (C) 1999 Elsevier Science Ltd.

Synthesis of isoquinolines from indanones: Total synthesis of illudinine

Schmidt reaction of 5-methoxy or 7-methoxyindan-1-ones or their derivatives results exclusively in isocarbostyrils which are converted into 6-methoxy or 8-methoxyisoquinolines in good yields.This strategy has been extended to the total synthesis of illudinine methyl ester (1b) starting from methyl 8-methoxy-2,2-dimethyl-7-oxo-1,2,3,5,6,7-hexahydro-s-indacene-4-carboxylate (4).