N-{3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}-6-[(2,4-dinitrophenyl)amino]hexanamide

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Chemical Name:N-{3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}-6-[(2,4-dinitrophenyl)amino]hexanamide
CAS No.:828293-27-2
Molecular Formula:C₅₁H₇₅N₇O₁₀S
Molecular Weight:978.263
Hs Code.:

Synonyms:N-{3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}-6-[(2,4-dinitrophenyl)amino]hexanamide

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Chemical Property of N-{3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}-6-[(2,4-dinitrophenyl)amino]hexanamide

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Technology Process of N-{3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}-6-[(2,4-dinitrophenyl)amino]hexanamide

There total 8 articles about N-{3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}-6-[(2,4-dinitrophenyl)amino]hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82321-04-8
6-(2,4-dinitrophenylamino)hexanoic acid N-hydroxysuccinimide ester

: 3-Amino-N-{3-[[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]-(2-nitro-benzenesulfonyl)-amino]-propyl}-propionamide

: 828293-27-2
N-{3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}-6-[(2,4-dinitrophenyl)amino]hexanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 6h;
DOI:10.1021/ja046663o

Reference yield:

: 474-77-1
epicholesterol

: 828293-27-2
N-{3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}-6-[(2,4-dinitrophenyl)amino]hexanamide

Guidance literature:: Multi-step reaction with 8 steps

1: 64 percent / HN₃; PPh₃; diethylazodicarboxylate / benzene; toluene / 2 h / 23 °C

2: LiAlH₄ / diethyl ether / 2 h / 4 - 23 °C

3: 3.50 g / diisopropylethylamine / tetrahydrofuran / 2 h / 23 °C

4: 78 percent / K₂CO₃ / N,N-dimethyl-acetamide / 20 h / 120 °C

5: trifluoroacetic acid / CH₂Cl₂ / 1 h / 23 °C

6: 103 mg / diisopropylethylamine / CH₂Cl₂ / 5 h / 23 °C

7: trifluoroacetic acid / CH₂Cl₂ / 1 h / 23 °C

8: 121 mg / diisopropylethylamine / CH₂Cl₂ / 6 h / 23 °C

With lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; toluene; benzene; 1: Mitsunobu reaction;
DOI:10.1021/ja046663o

Reference yield:

cholest-5-en-3-amine: 2126-93-4,14735-32-1,146727-50-6
cholest-5-en-3-amine

: 828293-27-2
N-{3-[(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)amino]-3-oxopropyl}-6-[(2,4-dinitrophenyl)amino]hexanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 3.50 g / diisopropylethylamine / tetrahydrofuran / 2 h / 23 °C

2: 78 percent / K₂CO₃ / N,N-dimethyl-acetamide / 20 h / 120 °C

3: trifluoroacetic acid / CH₂Cl₂ / 1 h / 23 °C

4: 103 mg / diisopropylethylamine / CH₂Cl₂ / 5 h / 23 °C

5: trifluoroacetic acid / CH₂Cl₂ / 1 h / 23 °C

6: 121 mg / diisopropylethylamine / CH₂Cl₂ / 6 h / 23 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/ja046663o