(+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline

Base Information

Chemical Name:(+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline
CAS No.:109741-34-6
Molecular Formula:C₁₉H₂₁NO₄
Molecular Weight:327.38
Hs Code.:

Synonyms:(+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline

Chemical Property:

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Technology Process of (+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline

There total 12 articles about (+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.9%

: 108017-85-2
5-(3-benzyloxy-4-methoxy-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

: 109741-34-6
(+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline

Guidance literature:: With hydrogen; pyrographite; palladium dichloride; In methanol; for 3.5h; under 2585.7 Torr; Ambient temperature;
DOI:10.1016/0223-5234(94)90126-0

Reference yield:

: (±)-ethyl 5-(3-((ethoxycarbonyl)oxy)-4-methoxybenzyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-6(5H)-carboxylate

: 109741-34-6
(+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Inert atmosphere; Reflux;
DOI:10.3762/bjoc.17.183

Reference yield:

: 1484-85-1
3,4-methylenedioxyphenylethylamine

: 109741-34-6
(+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 78.02 percent / xylene / 18 h / Heating

2: POCl₃ / toluene / 0.2 h / Heating

3: 91 percent / 3 h / Heating

4: 92 percent / NaBH₄ / CHCl₃; methanol / 0.5 h

5: 53.9 percent / H₂ / 2percent aq. PdCl₂, active carbon / methanol / 3.5 h / 2585.7 Torr / Ambient temperature

With sodium tetrahydroborate; hydrogen; trichlorophosphate; pyrographite; palladium dichloride; In methanol; chloroform; toluene; xylene;
DOI:10.1016/0223-5234(94)90126-0