N-[2-(1,3-Benzodioxole-5-yl)ethyl]4-methoxy-3-benzyloxyphenylacetamide

Base Information

Chemical Name:N-[2-(1,3-Benzodioxole-5-yl)ethyl]4-methoxy-3-benzyloxyphenylacetamide
CAS No.:73168-78-2
Molecular Formula:C₂₅H₂₅NO₅
Molecular Weight:419.477
Hs Code.:
European Community (EC) Number:651-852-0
Nikkaji Number:J1.255.888K

Synonyms:AKOS024322325;N-[2-(1,3-Benzodioxole-5-yl)ethyl]4-methoxy-3-benzyloxyphenylacetamide;N-(2-BENZO(1,3)DIOXOL-5-YL-ETHYL)-2-(3-BENZYLOXY-4-METHOXY-PHENYL)-ACETAMIDE

Suppliers and Price of N-[2-(1,3-Benzodioxole-5-yl)ethyl]4-methoxy-3-benzyloxyphenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(1,3-Benzodioxole-5-yl)ethyl]4-methoxy-3-benzyloxyphenylacetamide

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:419.17327290
Heavy Atom Count:31
Complexity:552

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CC(=O)NCCC2=CC3=C(C=C2)OCO3)OCC4=CC=CC=C4

Technology Process of N-[2-(1,3-Benzodioxole-5-yl)ethyl]4-methoxy-3-benzyloxyphenylacetamide

There total 2 articles about N-[2-(1,3-Benzodioxole-5-yl)ethyl]4-methoxy-3-benzyloxyphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.02%

: 5487-33-2
O-benzylhomoisovanillic acid

: 1484-85-1
3,4-methylenedioxyphenylethylamine

: 73168-78-2
N-(3,4-methylenedioxyphenethyl)-3-benzyloxy-4-methoxyphenylacetic acid amide

Guidance literature:: In xylene; for 18h; Heating;
DOI:10.1016/0223-5234(94)90126-0

Reference yield:

: 54313-33-6
2-(3-(benzyloxy)-4-methoxyphenyl)acetyl chloride

: 1484-85-1
3,4-methylenedioxyphenylethylamine

: 73168-78-2
N-(3,4-methylenedioxyphenethyl)-3-benzyloxy-4-methoxyphenylacetic acid amide

Guidance literature:: With sodium hydroxide; benzene;

Reference yield:

: 73168-78-2
N-(3,4-methylenedioxyphenethyl)-3-benzyloxy-4-methoxyphenylacetic acid amide

: 109741-34-6
(+/-)-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-2-methyl-6,7-methylenedioxyisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: POCl₃ / toluene / 0.2 h / Heating

2: 91 percent / 3 h / Heating

3: 92 percent / NaBH₄ / CHCl₃; methanol / 0.5 h

4: 53.9 percent / H₂ / 2percent aq. PdCl₂, active carbon / methanol / 3.5 h / 2585.7 Torr / Ambient temperature

With sodium tetrahydroborate; hydrogen; trichlorophosphate; pyrographite; palladium dichloride; In methanol; chloroform; toluene;
DOI:10.1016/0223-5234(94)90126-0