2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide S-oxide

Base Information

Chemical Name:2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide S-oxide
CAS No.:152038-58-9
Molecular Formula:C₂₂H₂₄N₄O₂S
Molecular Weight:408.524
Hs Code.:

Synonyms:2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide S-oxide

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Chemical Property of 2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide S-oxide

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Technology Process of 2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide S-oxide

There total 8 articles about 2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide S-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 152038-57-8
2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide

: 152038-58-9
2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide S-oxide

Guidance literature:: With sodium periodate; In methanol; water; for 408h; Ambient temperature;
DOI:10.1021/jo00077a016

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 152038-58-9
2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide S-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / i-Pr₂EtN / ethyl acetate / Ambient temperature

2: 88 percent / KO-t-Bu / dimethylsulfoxide / 0.25 h

3: 94 percent / dioxane / 5 h / 140 °C

4: 43 percent / sodium periodate / methanol; H₂O / 408 h / Ambient temperature

With sodium periodate; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00077a016

Reference yield:

: 38360-81-5
3,5-Dimethylthiophenol

: 152038-58-9
2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide S-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / i-Pr₂EtN / dioxane / 2 h / Ambient temperature

2: 94.9 percent / SnCl₂*2H₂O, conc. aq. HCl / acetic acid / 4 h / Ambient temperature

3: 66 percent / i-Pr₂EtN / ethyl acetate / Ambient temperature

4: 88 percent / KO-t-Bu / dimethylsulfoxide / 0.25 h

5: 94 percent / dioxane / 5 h / 140 °C

6: 43 percent / sodium periodate / methanol; H₂O / 408 h / Ambient temperature

With hydrogenchloride; sodium periodate; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In 1,4-dioxane; methanol; water; acetic acid; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00077a016