(5S)-5-benzyl-N-[(3,5-dimethoxyphenyl)acetyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide

Base Information

Chemical Name:(5S)-5-benzyl-N-[(3,5-dimethoxyphenyl)acetyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide
CAS No.:1430086-24-0
Molecular Formula:C₂₉H₂₉N₃O₇
Molecular Weight:531.565
Hs Code.:

Synonyms:(5S)-5-benzyl-N-[(3,5-dimethoxyphenyl)acetyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide

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Chemical Property of (5S)-5-benzyl-N-[(3,5-dimethoxyphenyl)acetyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide

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Technology Process of (5S)-5-benzyl-N-[(3,5-dimethoxyphenyl)acetyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide

There total 4 articles about (5S)-5-benzyl-N-[(3,5-dimethoxyphenyl)acetyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4670-10-4
(3,5-dimethoxyphenyl)acetic acid

: 1430086-21-7
(5S)-5-benzyl-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide

: 1430086-24-0
(5S)-5-benzyl-N-[(3,5-dimethoxyphenyl)acetyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 607-81-8
diethyl 2-benzylmalonate

: 1430086-24-0
(5S)-5-benzyl-N-[(3,5-dimethoxyphenyl)acetyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: cesium fluoride / N,N-dimethyl-formamide / 72 h / 40 °C

2.1: sodium hydroxide / tetrahydrofuran / 0.08 h / 0 °C / Molecular sieve; Inert atmosphere

2.2: 4.5 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

3.1: hydrazine / methanol / 1 h / Sonication; Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; cesium fluoride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; hydrazine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1430086-17-1
ethyl (5S)-5-benzyl-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carboxylate

: 1430086-24-0
(5S)-5-benzyl-N-[(3,5-dimethoxyphenyl)acetyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / methanol / 1 h / Sonication; Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; hydrazine; In methanol; dichloromethane;