N'-[(4-trifluoromethylphenyl)methylene]-(4-oxo-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Base Information

Chemical Name:N'-[(4-trifluoromethylphenyl)methylene]-(4-oxo-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone
CAS No.:1345512-58-4
Molecular Formula:C₂₀H₁₇F₃N₄O₂S
Molecular Weight:434.442
Hs Code.:

Synonyms:N'-[(4-trifluoromethylphenyl)methylene]-(4-oxo-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

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Chemical Property of N'-[(4-trifluoromethylphenyl)methylene]-(4-oxo-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

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Technology Process of N'-[(4-trifluoromethylphenyl)methylene]-(4-oxo-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

There total 5 articles about N'-[(4-trifluoromethylphenyl)methylene]-(4-oxo-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 162884-74-4
(4-oxo-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d]pyrimidin-3-yl)acetic acid hydrazide

: 1345512-58-4
N'-[(4-trifluoromethylphenyl)methylene]-(4-oxo-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Guidance literature:: In butan-1-ol; at 110 ℃; for 12h;
DOI:10.1016/j.bmcl.2011.09.061

Reference yield:

: 4506-71-2
ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 1345512-58-4
N'-[(4-trifluoromethylphenyl)methylene]-(4-oxo-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.5 h / 200 °C

2: potassium carbonate / acetone / 48 h / 55 °C

3: hydrazine / ethanol / 12 h / Reflux

4: butan-1-ol / 12 h / 110 °C

With potassium carbonate; hydrazine; In ethanol; acetone; butan-1-ol;
DOI:10.1016/j.bmcl.2011.09.061

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1345512-58-4
N'-[(4-trifluoromethylphenyl)methylene]-(4-oxo-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Guidance literature:: Multi-step reaction with 5 steps

1: morpholine; aluminum oxide; sulfur / 0.25 h / Microwave irradiation

2: 1.5 h / 200 °C

3: potassium carbonate / acetone / 48 h / 55 °C

4: hydrazine / ethanol / 12 h / Reflux

5: butan-1-ol / 12 h / 110 °C

With morpholine; aluminum oxide; potassium carbonate; sulfur; hydrazine; In ethanol; acetone; butan-1-ol;
DOI:10.1016/j.bmcl.2011.09.061