methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

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Chemical Name:methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate
CAS No.:1562195-36-1
Molecular Formula:C₂₄H₁₇F₅N₂O₃
Molecular Weight:476.403
Hs Code.:

Synonyms:methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

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Chemical Property of methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

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Technology Process of methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

There total 8 articles about methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 13061-96-6
dihydroxy-methyl-borane

: 1562195-07-6
methyl 4-(1-(2-bromo-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

: 1562195-30-5
methyl 5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

: 1562195-36-1
methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; water; at 100 ℃; for 16h;

Reference yield:

: 341-23-1
4-fluoro-1H-indazole

: 1562195-30-5
methyl 5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

: 1562195-36-1
methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C

2: toluene-4-sulfonic acid / tetrahydrofuran / 6 h / Reflux

3: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

4: hydrogenchloride; methanol / 14 h / Reflux

5: caesium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C

6: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 16 h / 100 °C

With hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; 3: |Suzuki Coupling;

Reference yield:

: 518990-32-4
4-fluoro-3-iodo-1H-indazole

: 1562195-30-5
methyl 5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

: 1562195-36-1
methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / 6 h / Reflux

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

3: hydrogenchloride; methanol / 14 h / Reflux

4: caesium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C

5: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 16 h / 100 °C

With hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;